Publications by authors named "A Ostertag"
Article Synopsis
- Osteogenesis imperfecta (OI) is a genetic bone disorder that leads to frequent fractures, but the link between bone mineral density (BMD) and fracture risk in adults with OI is unclear.
- A study of 71 individuals with OI showed consistently low BMD at the lumbar spine, with no significant changes over a median follow-up of 5.1 years.
- The research found that a lower baseline BMD (Z-score <-2) and specific genetic variants in the COL1 gene increased the likelihood of fractures.
Article Synopsis
- - X-linked Hypophosphatemia (XLH) is a common inherited rickets condition, but its effects on bone structure and properties are not well understood; this study analyzed bone characteristics in adults with XLH compared to healthy controls.
- - Findings showed that patients had higher areal bone mineral density (aBMD) and trabecular bone scores at the lumbar spine, but lower volumetric BMD and trabecular measures at the distal radius, indicating mixed bone quality.
- - Over time, a follow-up revealed declines in total and cortical volumetric BMD at the tibia, suggesting that while XLH patients have some higher densities initially, microarchitectural issues worsen with age.
Context: The association of obesity with bone fragility fractures is complex and non-linear. Despite good efficacy on weight loss, bariatric surgery (BS) is also associated with bone loss. However, we lack information on risk factors of the long-term deleterious effects of BS on the skeleton.
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- Zebrafish are being extensively used to study bone development and diseases, emphasizing the need to understand how osteoblasts differentiate and function.
- Researchers isolated specific osteoblast subpopulations from young zebrafish to examine their unique genetic and signaling characteristics.
- Mutations in genes related to extracellular matrix proteins showcased significant alterations in skeletal structure and mineral density in zebrafish, underlining the proteins' crucial role in bone development and maintenance.
Bismuth is a xenobiotic metal with a high affinity to sulfur that is used in a variety of therapeutic applications. Bi(III) induces the cysteine-rich metallothionein (MT), a protein known to form two-domain cluster structures with certain metals such as Zn(II), Cd(II), or Cu(I). The binding of Bi(III) to MTs has been previously studied, but there are conflicting reports on the stoichiometry and binding pathway, which appear to be highly dependent on pH and initial metal-loading status of the MT.
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