Immunoinformatic design of a multivalent vaccine against and its evaluation in a murine model using a DNA prime-protein boost strategy.

Introduction: The development of effective vaccines against is critical due to its significant impact on human and animal health. The objective of this study was to design and evaluate and a multivalent vaccine based on the immunogenic potential of three selected open reading frames (ORFs) of .

Methods: The designed construct, named S22, was analyzed to evaluate its physicochemical properties, antigenicity, allergenicity and toxicity.

Dataset on physical-chemical and marine water quality variables in San Andrés Island, Colombian Caribbean.

In situ measurements and laboratory analysis considering i) marine water quality measurements, ii) Physical, chemical, and heavy metals characteristics of desalination brine, and iii) Conductivity- Temperature-Depth (CTD) profiles, were conducted. For marine water quality, the data collection aimed to evaluate the distribution of salinity, temperature, and heavy metals both at the surface and close to the seabed and other water quality parameters at specific locations. For salinity and temperature, a salinity tester model HQ40d was used.

Longitudinal associations of spousal support and strain with health and well-being: An outcome-wide study of married older U.S. Adults.

In the present study, we examined the prospective associations of both spousal support and spousal strain with a wide range of health and well-being outcomes in married older adults. Applying the analytic template for outcome-wide designs, three waves of longitudinal data from the Health and Retirement Study (n = 7788, M = 64.2 years) were analyzed using linear regression, logistic regression, and generalized linear models.

Genes required for phosphosphingolipid formation in Caulobacter crescentus contribute to bacterial virulence.

Sphingolipids are ubiquitous in membranes of eukaryotes and are associated with important cellular functions. Although sphingolipids occur scarcely in bacteria, for some of them they are essential and, in other bacteria, they contribute to fitness and stability of the outer membrane, such as in the well-studied α-proteobacterium Caulobacter crescentus. We previously defined five structural genes for ceramide synthesis in C.