Publications by authors named "A Opipari"
Article Synopsis
- - This study assessed the safety, tolerability, and pharmacokinetics of DFV890, an oral NLRP3 inhibitor, in 122 healthy participants through a three-part trial involving single and multiple doses.
- - DFV890 was well-tolerated with no serious adverse events, showing a dose-proportional increase in exposure in the adjusted formulation, while food intake significantly affected its pharmacokinetic profile.
- - The drug effectively inhibited IL-1β release, maintaining about 90% inhibition over 24 hours with specific dosing regimens, suggesting its potential for treating conditions involving NLRP3 overactivation.
Background And Aims: Inflammatory bowel diseases (IBD) are characterized by mucosal inflammation and sequential fibrosis formation, but the exact role of the hyperactive NLRP3 inflammasome in these processes is unclear. Thus, we studied the expression and function of the NLRP3 inflammasome in the context of inflammation and fibrosis in IBD.
Methods: We analysed intestinal NLRP3 expression in mucosal immune cells and fibroblasts from IBD patients and NLRP3-associated gene expression via single-cell RNA sequencing and microarray analyses.
Background: Oral and rectal formulations of 5-aminosalicylic acid are the first-line therapy for mild-to-moderate, distal ulcerative colitis (UC), but such a treatment is not effective in one-third of patients. Niclosamide is a small molecule, developed and approved as an orally administered drug to treat helminthic infections, with an excellent safety profile. Preclinical work showed that niclosamide is an anti-inflammatory agent, thereby providing the rationale to explore its safety and efficacy in patients with UC.
View Article and Find Full Text PDFT cell proliferation and cytokine production are bioenergetically and biosynthetically costly. The inability to meet these metabolic demands results in altered differentiation, accompanied by impaired effector function, and attrition of the immune response. Interleukin-17-producing CD4 T cells (T17s) are mediators of host defense, autoimmunity, and antitumor immunity in the setting of adoptive T cell therapy.
View Article and Find Full Text PDFRobots working in human environments often encounter a wide range of articulated objects, such as tools, cabinets, and other jointed objects. Such articulated objects can take an infinite number of possible poses, as a point in a potentially high-dimensional continuous space. A robot must perceive this continuous pose to manipulate the object to a desired pose.
View Article and Find Full Text PDF