Publications by authors named "A Olschewski"
Polyester biomaterials play a crucial in vascular surgery, but suffer from unspecific protein adsorption, thrombogenicity, and inadequate endothelial cell response, which limit their success. To address these issues, we investigated the functionalization of polyester biomaterials with antithrombogenic polysaccharide coatings. A two-step and water-based method was used to coat cationized polycaprolactone with different sulfated polysaccharides (SPS), which resulted in long-term stability, tunable morphology, roughness, film thickness, chemical compositions, zeta potential, and water content.
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- Major advances have been made in understanding the cellular and molecular mechanisms involved in various types of pulmonary hypertension, but survival rates are still low, highlighting the need for better healthcare interventions.
- Recent discussions from the 7th World Symposium on Pulmonary Hypertension emphasize the importance of new findings in pathology and pathophysiology, questioning their relevance to different forms of the condition.
- The exploration of omics and technological advancements aims to improve our understanding of pulmonary vascular remodelling and to enhance patient care, drug development, and research in this area.
In an aging society, unveiling new anti-aging strategies to prevent and combat aging-related diseases is of utmost importance. Mitochondria are the primary ATP production sites and key regulators of programmed cell death. Consequently, these highly dynamic organelles play a central role in maintaining tissue function, and mitochondrial dysfunction is a pivotal factor in the progressive age-related decline in cellular homeostasis and organ function.
View Article and Find Full Text PDFBackground And Purpose: Pulmonary arterial hypertension (PAH) is a progressive disease in which chronic membrane potential (E) depolarisation of the pulmonary arterial smooth muscle cells (PASMCs) causes calcium overload, a key pathological alteration. Under resting conditions, the negative E is mainly set by two pore domain potassium (K) channels, of which the TASK-1 has been extensively investigated.
Experimental Approach: Ion channel currents and membrane potential of primary cultured human(h) PASMCs were measured using the voltage- and current clamp methods.