Publications by authors named "A Olgac"
The inhibition of human microsomal prostaglandin E (PGE) synthase-1 (mPGES-1) is a promising therapeutic modality for developing next-generation anti-inflammatory medications. In this study, we present novel 2-phenylbenzothiazole derivatives featuring heteroaryl sulfonamide end-capping substructures as inhibitors of human mPGES-1, with IC values in the range of 0.72-3.
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- mPGES-1 is highlighted as a key target for developing treatments for inflammation and pain, with the study introducing new benzimidazole compounds that effectively inhibit this enzyme.
- One of the compounds, AGU654, showed exceptional selectivity for mPGES-1 over other related enzymes, with a low inhibition concentration (IC = 2.9 nM) and promising bioavailability.
- AGU654 was able to reduce PGE production from activated immune cells without affecting other prostaglandins, and it also demonstrated success in alleviating fever and pain in guinea pig models, indicating its potential for managing inflammatory diseases.
Introduction: Leigh syndrome is a rare mitochondrial disorder characterized by subacute necrotizing encephalomyelopathy, resulting from defects in mitochondrial respiratory enzymes or pyruvate dehydrogenase complex. Symptoms can manifest in infancy, childhood, or adulthood. We present a case of a 7-month-old girl initially misdiagnosed with septic shock but was later found to have Leigh encephalomyelopathy due to deficiency.
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- Nephrotic syndrome can arise from various causes, including metabolic disorders like cobalamin C (cblC) defect, which is linked to mutations in the MMACHC gene affecting vitamin B12 processing and is usually characterized by hematological and neurological symptoms.
- A 7-month-old male patient's case is presented, showcasing symptoms such as fatigue, edema, and laboratory findings that indicated anemia and proteinuria, eventually leading to a diagnosis of nephrotic syndrome caused by the cblC defect confirmed by genetic testing.
- The case emphasizes the importance of identifying metabolic conditions in atypical nephrotic syndrome presentations and suggests that early detection and management can prevent serious complications, such as irreversible renal damage.