Publications by authors named "A Oleksik"
Upon publication of this article [1], it was noticed that there were some inconsistencies in Tables 1, 2 and 3. Some of the superscript letters were incorrectly assigned. Please see below the correct tables.
View Article and Find Full Text PDFBackground: Cerebrovascular disease (CVD) and amyloid-β (Aβ) often coexist, but their influence on neurodegeneration and cognition in predementia stages remains unclear. We investigated the association between CVD and Aβ on neurodegenerative markers and cognition in patients without dementia.
Methods: We included 271 memory clinic patients with subjective or objective cognitive deficits but without dementia from the BioBank Alzheimer Center Limburg cohort (n = 99) and the LeARN (n = 50) and DESCRIPA (n = 122) multicenter studies.
In patients with postmenopausal osteoporosis low bone volume is associated with high bone marrow adipose tissue (MAT). Moreover, high MAT is associated with increased fracture risk. This suggests an interaction between MAT and bone turnover, however literature remains equivocal.
View Article and Find Full Text PDFIntroduction: We aimed to determine the added value of cerebrospinal fluid (CSF) to clinical and imaging tests to predict progression from mild cognitive impairment (MCI) to any type of dementia.
Methods: The risk of progression to dementia was estimated using two logistic regression models based on 250 MCI participants: the first included standard clinical measures (demographic, clinical, and imaging test information) without CSF biomarkers, and the second included standard clinical measures with CSF biomarkers.
Results: Adding CSF improved predictive accuracy with 0.
Article Synopsis
- Neuropsychological assessments (NPA) were evaluated to determine their added value alongside standard clinical evaluations in memory clinic patients.
- In a study with 221 patients, NPA led to significant changes in diagnoses: 22% of syndromal diagnoses and 15% of etiological diagnoses were updated based on NPA findings.
- The inclusion of NPA improved diagnostic accuracy by 18% for syndromal diagnoses and increased clinician confidence by 6-7% overall, especially benefiting patients with subjective cognitive impairment (SCI) and mild cognitive impairment (MCI).