Publications by authors named "A Olch"
The time-consuming process of manual contouring of healthy tissue and organs in radiation therapy has prompted the development of computational systems to aid and automate this process, such as artificial intelligence (AI) segmentation and interpolation algorithms. These algorithms are useful in saving time, however, they are not always accurate. Fixing such inaccuracies by editing contours is a manual, time-consuming process as no 'undo' feature currently exists in the most commonly used treatment planning system (TPS).
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- Children with posterior fossa tumors treated with cranial irradiation (CRT) often experience significant cognitive deficits, affecting areas like spatial learning and memory compared to healthy peers.
- Neuroimaging revealed that those receiving CRT had smaller thalamic volumes and negative correlations between radiation doses to the hippocampus and cognitive performance.
- The study indicates that cranial irradiation can adversely impact critical brain structures, resulting in long-term cognitive challenges for affected children.
Validation of Acuros for total body irradiation at extended distance.
J Appl Clin Med Phys
September 2024
Purpose: Standardized and accurately reported doses are essential in conventional total body irradiation (TBI), especially lung doses. This study evaluates the accuracy of the Acuros algorithm in predicting doses for extended-distance TBI.
Methods: Measurements and calculations were done with both 6 and 18 MV.
Reporting Standards for Complication Studies of Radiation Therapy for Pediatric Cancer: Lessons From PENTEC.
Int J Radiat Oncol Biol Phys
June 2024
The major aim of Pediatric Normal Tissue Effects in the Clinic (PENTEC) was to synthesize quantitative published dose/-volume/toxicity data in pediatric radiation therapy. Such systematic reviews are often challenging because of the lack of standardization and difficulty of reporting outcomes, clinical factors, and treatment details in journal articles. This has clinical consequences: optimization of treatment plans must balance between the risks of toxicity and local failure; counseling patients and their parents requires knowledge of the excess risks encountered after a specific treatment.
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- Radiation oncology balances the benefits and risks of high doses of ionizing radiation on tumors and normal tissues, which is crucial for childhood cancer survivors (CCS) who may face significant long-term consequences.
- The Pediatric Normal-Tissue Effects in the Clinic (PENTEC) network aims to analyze and compile dose-volume-response relationships related to adverse events in CCS to guide safer radiation therapy decisions.
- Challenges in studying CCS include their rarity, diverse cancer types, increased health risks beyond radiation exposure, variable study methodologies, and the long delay before adverse effects manifest, complicating risk assessments and data synthesis.