Publications by authors named "A Okagaki"
TTR exon-humanized mouse optimal for verifying new therapies for FAP.
Biochem Biophys Res Commun
April 2022
Familial amyloidotic polyneuropathy (FAP) is caused by a mutation in the transthyretin (TTR) gene. In addition, deposition of wild-type TTR can cause senile systemic amyloidosis (SSA). To date, we have produced several transgenic mouse models for FAP and SSA by introducing TTR genes with different promoters or mutations.
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- Pseudo-Meigs syndrome occurs when there's fluid accumulation in the abdomen and chest due to a pelvic tumor that's not a benign ovarian mass, and it often resolves after the tumor is surgically removed.
- A case involving a 37-year-old woman with a large uterine leiomyoma (fibroid) was initially misdiagnosed as ovarian cancer due to symptoms like abdominal swelling and anorexia.
- After surgical removal of the tumor and a small cyst in the ovary, the patient's symptoms improved, and she was diagnosed with pseudo-Meigs syndrome since there was no evidence of cancer, and her fluid levels returned to normal.
We report 3 cases of extrapulmonary lymphangioleiomyomatosis incidentally found in pelvic and paraaortic lymph nodes in association with uterine cancers. Three women, 47-year-old, 59-year-old, and 71-year-old, respectively, had uterine cancers and underwent hysterectomy, bilateral salpingo-oophorectomy, and pelvic and paraaortic lymph node excision. None of the 3 patients had tuberous sclerosis complex or lymphangioleiomyomatosis in other organs.
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- Extrapulmonary small cell carcinomas often coexist with other types of carcinomas, leading to theories about their origin, including the possibility of arising from a multipotential stem cell.
- Recent molecular evidence suggests that the small cell component may develop later in the progression of typical organ carcinomas.
- A case study of uterine cervical adenocarcinoma revealed a 30% small cell carcinoma component, with clear transitional boundaries, supporting the idea that small cell carcinoma can develop from pre-existing adenocarcinomas.
Budd-Chiari syndrome is a rather unusual clinical situation caused by occlusion of the hepatic vein of inferior vena cava, the classical triad of which are abdominal pain, ascites and hepatomegaly. A 29-year-old gravida 3 para 1 woman delivered an immature male baby weighing 2172 g with an Apgar score of 9 points at 35 weeks and 3 days of gestation. She was transferred to the National Hospital Organization Osaka National Hospital 112 days after delivery due to the sudden development of massive ascites.
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