Publications by authors named "A Oishi"
Objectives: This study aimed to elucidate the roles of Prrx1 and Prrx2, homeobox transcription factors, in tooth development and determine whether Prrx2 regulates pannexin 3 (Panx3) expression, which is important in preodontoblasts.
Methods: Tooth sections were prepared from 13.5-, 15.
Article Synopsis
- The study aimed to simulate and evaluate how disease stage, VF test frequency, clustering, and eye inclusion impact sample size calculations in retinitis pigmentosa clinical trials.
- VF tests were conducted across different disease stages, measuring the probability of detecting significant treatment effects at various levels, with data collected over approximately two years.
- Results indicated that using only one eye could significantly reduce the required sample size for detecting treatment differences, especially in moderate disease stages, while early disease stages and including both eyes also influenced this requirement.
Tissue clearing, coupled with immunostaining, enables the transition from two-dimensional to three-dimensional pathology and has the potential to substantially improve data quality for biomedical diagnostics. Nevertheless, the workflows are limited by the complex sample processing protocols. Approaches for the parallel processing of samples, to include tissue clearing, immunostaining, imaging and analysis can increase three-dimensional pathology throughput.
View Article and Find Full Text PDF: Neuronal intranuclear inclusion disease (NIID) is a progressive neurodegenerative disorder characterized by the formation of intranuclear inclusions in cells. Adult-type NIID usually develops in elderly patients with various clinical manifestations and is sometimes accompanied by ocular symptoms. A case of adult-onset NIID with early and unique manifestations, including a progressive corneal defect and retinal changes, which are concerning at a young age, is reported.
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