Publications by authors named "A Ohtori"
In Silico Ocular Pharmacokinetic Modeling: Delivery of Topical FK962 to Retina.
J Ocul Pharmacol Ther
September 2017
Article Synopsis
- The study aimed to create a computer-based model to understand how the eye drop FK962 behaves in the eye, specifically for treating choroid/retinal diseases.
- It involved testing FK962 in rabbits and measuring how well it moves through different layers of the eye, as well as its effect on retinal cells.
- The results showed that the model accurately predicts drug concentrations in the eye and suggests an effective dosing schedule for FK962, which could be beneficial for clinical trials focusing on retinal health.
Purpose: To investigate the efficacy of a topical hydrogel ring for drug delivery to the posterior segment of the rabbit eye.
Materials And Methods: Novel hydrogel corneal lenses (CL), scleral/corneal lenses (S/CL), and rings were prepared using poly(hydroxyethyl methacrylate). The devices were immersed in 0.
Article Synopsis
- The study investigated the effects of FK962, a drug, on nerve growth and recovery of corneal sensitivity in rabbits after creating a corneal flap.
- FK962 was found to promote nerve elongation in lab cultures and significantly improved axonal regeneration and sensitivity in the corneas of treated rabbits compared to untreated ones.
- The findings suggest that FK962 could potentially reduce complications for patients undergoing LASIK surgery by enhancing corneal re-innervation and sensitivity recovery.
Drug penetration of the posterior eye tissues after topical instillation: in vivo and in silico simulation.
Chem Pharm Bull (Tokyo)
June 2012
The purpose of this study was to analyze drug pharmacokinetics in the posterior eye tissues after topical instillation. For the in vivo study, the concentrations of ofloxacin in rabbit ocular tissues were analyzed by high performance liquid chromatography at 1, 2, and 3 h after instillation. For the in silico simulation, the concentration distribution of ofloxacin in the eye was calculated by the ocular pharmacokinetic model based on the diffusion/partition model.
View Article and Find Full Text PDFEffects of pathological conditions on ocular pharmacokinetics of antimicrobial drugs.
Chem Pharm Bull (Tokyo)
October 2010
A diffusion model of ocular pharmacokinetics was used to estimate the effects of pathological conditions on ocular pharmacokinetics. In vivo rabbit data after topical instillation of ciprofloxacin and ofloxacin were compared with the simulated concentrations in the aqueous and vitreous humors. The barrier capacity of the surrounding membranes such as the retina/choroid/sclera (RCS) membrane and the cornea was characterized by dimensionless Sherwood number derived by the pseudo-steady state approach (PSSA).
View Article and Find Full Text PDF