Publications by authors named "A Odriozola"
Background/objective: Colorectal cancer (CRC) is one of the most common cancers worldwide. Increasing scientific evidence supports the idea that gut microbiota dysbiosis accompanies colorectal tumorigenesis, and these changes could be causative. Implementing gut microbiota analysis in clinical practice is limited by sample type, sequencing platform and taxonomic classification.
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- The incomplete understanding of epididymal mucosal immunity complicates the diagnosis of many male infertility cases, often leaving them labeled as idiopathic.
- Disruptions like vasectomy or infections can trigger immune responses against sperm, leading to autoimmune reactions and chronic subfertility issues.
- The research highlights the role of regulatory T cells and the formation of tertiary lymphoid structures in the epididymis, indicating potential avenues for targeted infertility treatments and male contraceptive developments.
Article Synopsis
- * The article discusses how CRC develops from the transformation of normal cells in colonic crypts, outlining both the classical and alternative pathways that lead to CRC, each linked to distinct molecular mechanisms and genetic instabilities.
- * Various CRC classification systems informed by genetic, epigenetic, and transcriptomic changes are introduced, highlighting their importance for personalized diagnosis and treatment.
Colorectal cancer (CRC) ranks second in incidence and third in cancer mortality worldwide. This situation, together with the understanding of the heterogeneity of the disease, has highlighted the need to develop a more individualised approach to its prevention, diagnosis and treatment through personalised medicine. This approach aims to stratify patients according to risk, predict disease progression and determine the most appropriate treatment.
View Article and Find Full Text PDFColorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related death worldwide. In recent years, the impact of the gut microbiota on the development of CRC has become clear. The gut microbiota is the community of microorganisms living in the gut symbiotic relationship with the host.
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