Publications by authors named "A Oden"

Background: Ivacaftor exhibits anti-staphylococcal properties but does not clear from the lungs of people with cystic fibrosis (pwCF). We assessed whether exposure to therapeutic concentrations of ivacaftor could allow to form small colony variants (SCVs), a phenotype commonly associated with bacterial persistence.

Methods: Humanized G551D-CFTR (hG551D) rats were treated with ivacaftor for 7 days.

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Background: Newly approved highly effective modulation therapies (HEMT) have been life-changing for people with CF. Although these drugs have resulted in significant improvements in lung function and exacerbation rate, bacterial populations in the lung have not been eradicated. The mechanisms behind the continued colonization are not completely clear.

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Article Synopsis
  • Cystic fibrosis (CF) patients often suffer from lung infections, primarily caused by Pseudomonas aeruginosa and Staphylococcus aureus, leading to severe respiratory issues.
  • The study used CF rats to examine how different strains of S. aureus (normal and small colony variants) interact with P. aeruginosa and affect lung health.
  • Results showed that rats with normal colony S. aureus and P. aeruginosa faced more lung damage compared to those with SCV S. aureus, suggesting that certain S. aureus strains can influence the progression of CF-related lung decline.
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In cystic fibrosis, the airway gel-forming mucin MUC5B accumulates in the airways, preventing clearance of pathogens like (PA). The cystic fibrosis transmembrane conductance regulator (CFTR) (KO) rat model exhibits a similar accumulation of Muc5b. Our lab has shown that increased Muc5b precipitates the development of chronic PA infection.

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Introduction: Whereas several studies show that homozygous (HbSS) sickle cell disease protects against human immunodeficiency virus infection, it is not clear if human immunodeficiency virus infection is affected by the heterozygous state of the sickle globin gene (HbAS or sickle cell trait).

Objective: To evaluate the effects of sickle cell trait on the prevalence and severity of human immunodeficiency virus type 1 infection in a large patient population.

Methods: Hemoglobin genotype was determined by high performance liquid chromatography (HPLC) in 1,226 HIV-1 patients in Nigeria.

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