Publications by authors named "A Odainic"
Article Synopsis
- - Microglia play a vital role in brain health by connecting to neurons through tunneling nanotubes (TNTs), allowing the quick exchange of essential materials.
- - In neurodegenerative diseases, microglia utilize these TNTs to help neurons eliminate toxic protein aggregates like alpha-synuclein and tau, thereby improving neuronal health and function.
- - Genetic mutations in microglia, such as Lrrk2(Gly2019Ser) and Trem2 variants, hinder their ability to transfer protective materials to neurons, highlighting their potential involvement in neurodegenerative disease progression.
Understanding tissue biology's heterogeneity is crucial for advancing precision medicine. Despite the centrality of the immune system in tissue homeostasis, a detailed and comprehensive map of immune cell distribution and interactions across human tissues and demographics remains elusive. To fill this gap, we harmonised data from 12,981 single-cell RNA sequencing samples and curated 29 million cells from 45 anatomical sites to create a comprehensive compositional and transcriptional healthy map of the healthy immune system.
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- * Variants of UNC93B1 (E92G and R336L) were found in patients with early-onset systemic lupus erythematosus (SLE), correlating with heightened inflammatory responses when stimulated by TLR7/TLR8 agonists.
- * The E92G variant destabilizes the UNC93B1 protein, leading to increased TLR7 activity and type I interferon signaling, pointing to a potential therapeutic target for managing SLE by focusing on TLR7.
The blood proteome holds great promise for precision medicine but poses substantial challenges due to the low abundance of most plasma proteins and the vast dynamic range of the plasma proteome. Here we address these challenges with NUcleic acid Linked Immuno-Sandwich Assay (NULISA™), which improves the sensitivity of traditional proximity ligation assays by ~10,000-fold to attomolar level, by suppressing assay background via a dual capture and release mechanism built into oligonucleotide-conjugated antibodies. Highly multiplexed quantification of both low- and high-abundance proteins spanning a wide dynamic range is achieved by attenuating signals from abundant targets with unconjugated antibodies and next-generation sequencing of barcoded reporter DNA.
View Article and Find Full Text PDFHeadache is one of the most common neurological manifestations of COVID-19, but it is unclear whether chronic headache as a symptom of Post-COVID-19 is associated with ongoing CNS damage. We compared cerebrospinal fluid (CSF) levels of markers of CNS damage and inflammation in Post-COVID-19 patients with persistent headache to hospitalized acute COVID-19 patients with neurological symptoms and to non-COVID-19 disease-controls. CSF levels of neurofilament light chain, Ubiquitin carboxyl-terminal hydrolase L1 and Tau were similar in patients with persistent headache in post-COVID-19 compared to acute COVID-19 patients and all control groups.
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