Publications by authors named "A O Tokareva"
Background/objectives: The development of blood tests for the early detection of individual predisposition to socially significant diseases remains a pressing issue.
Methods: In this pilot study, multiple reaction monitoring mass spectrometry (MRM-MS) with a BAK-270 assay was applied for protein concentrations analysis in blood plasma from 21 healthy volunteers of the European cohort.
Results: The levels of 138 plasma proteins were reliably and precisely quantified in no less than 50% of samples.
Article Synopsis
- - Diet therapy is the main strategy for managing hyperglycemia, especially in pregnant women with gestational diabetes mellitus (GDM), as it can affect the blood lipid profile and fetal development.
- - A study involved 110 pregnant women, looking at blood samples across trimesters to assess how adherence to diet therapy influenced lipid composition and newborn weight.
- - Results showed that diet therapy significantly impacts blood lipid levels during pregnancy, helping to normalize both carbohydrate and lipid metabolism, which could improve the outlook for fetal macrosomia issues.
Article Synopsis
- Preeclampsia (PE) is a serious pregnancy condition affecting up to 5% of pregnant women, leading to significant health risks for both mothers and newborns, with a need for better early risk assessment methods.
- A study identified ten maternal serum proteins as potential early markers for PE at 11-13 weeks gestation, with most of these proteins having connections to PE from previous research.
- A Support Vector Machine (SVM) model using 19 proteins showed a high predictive power (AUC of 0.91, 87% sensitivity, 95% specificity) for early PE detection, outperforming standard screening methods.
Polycystic ovary syndrome (PCOS) is a complex disorder that impacts both the endocrine and metabolic systems, often resulting in infertility, obesity, insulin resistance, and cardiovascular complications. The aim of this study is to investigate the role of intestinal flora and its metabolites, particularly short-chain fatty acids (SCFAs), in the development of PCOS, and to assess the effects of metformin therapy on these components. SCFA levels in fecal and blood samples from women with PCOS (n=69) and healthy controls (n=18) were analyzed using Gas Chromatography-Mass Spectrometry (GC/MS) for precise measurement.
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- * This study analyzes the lipid profiles from menstrual blood samples of women with and without endometriosis to identify specific lipid markers that could aid in diagnosis.
- * Key findings reveal that certain lipids, such as specific ceramides and cardiolipins, are altered in women with endometriosis, and two particular lipids showed promising diagnostic accuracy with 81% sensitivity and 85% specificity.