Publications by authors named "A O Sheets"
Multimodality imaging of pulmonary artery aneurysms due to giant cell arteritis: a case series.
Int J Cardiovasc Imaging
October 2024
Article Synopsis
- Pulmonary artery aneurysms (PAAs) are uncommon but significant vascular issues that can present with vague symptoms, with some patients being asymptomatic while others may experience chest pain or difficulty breathing.
- PAAs can be caused by various factors including congenital conditions, acquired factors, and unknown origins, with giant cell arteritis (GCA) being a rare cause outlined in limited case reports.
- This case series presents an analysis of four patients diagnosed with isolated PAAs attributed to GCA, focusing on their clinical presentations, diagnostic imaging techniques, and treatment options.
Introduction: We used a Programme Science platform, to generate evidence to support the implementation of programmes for sex workers in Africa. Female sex workers are estimated to make up 1.6% (1.
View Article and Find Full Text PDFThe Wilderness Medical Society convened a panel to review available evidence supporting practices for medical direction of search and rescue teams. This panel included of members of the Wilderness Medical Society Search and Rescue Committee, the National Association of EMS Physicians Wilderness Committee, and leadership of the Mountain Rescue Association. Literature about definitions and terminology, epidemiology, currently accepted best practices, and regulatory and legal considerations was reviewed.
View Article and Find Full Text PDFOral gepotidacin versus nitrofurantoin in patients with uncomplicated urinary tract infection (EAGLE-2 and EAGLE-3): two randomised, controlled, double-blind, double-dummy, phase 3, non-inferiority trials.
Lancet
February 2024
Background: Gepotidacin is a novel, bactericidal, first-in-class triazaacenaphthylene antibiotic that inhibits bacterial DNA replication by a distinct mechanism of action and a unique binding site, providing well balanced inhibition of two type II topoisomerase enzymes. Oral gepotidacin is under investigation to treat uncomplicated urinary tract infections. We aimed to compare the efficacy and safety of oral gepotidacin with that of nitrofurantoin in adolescent and adult female individuals with uncomplicated urinary tract infections.
View Article and Find Full Text PDFBackground: Dedicator of cytokinesis 8 (DOCK8)-deficient patients have severe eczema, elevated IgE, and eosinophilia, features of atopic dermatitis (AD).
Objective: We sought to understand the mechanisms of eczema in DOCK8 deficiency.
Methods: Skin biopsy samples were characterized by histology, immunofluorescence microscopy, and gene expression.