The Clinical Evolution of Diffuse Myocardial Fibrosis in Patients With Arterial Hypertension and Heart Failure With Mildly Reduced Ejection Fraction Treated by Olmesartan or Sacubitril / Valsartan.

Aim      A 12-month evaluation of the potentialities of the angiotensin II receptor inhibitor olmesartan (Olme) and the angiotensin receptor and neprilysin inhibitor (ARNI) sacubitril/valsartan in patients with arterial hypertension (AH) and dyslipidemia in the dynamics of the following indicators of chronic heart failure (CHF): N-terminal pro-brain natriuretic peptide (NT-proBNP), left ventricular ejection fraction (LVEF), LV global longitudinal strain (LV GLS) in diffuse myocardial fibrosis (MF) previously diagnosed by magnetic resonance imaging (MRI).Material and methods  Olmesartan medoxomil (n=56) and sacubitril/valsartan (n=63) were used for 12 months in patients with hypertension, dyslipidemia and NYHA functional class II-III CHF with mid-range LVEF (CHFmrEF). MF was diagnosed by the following MRI criteria: late gadolinium enhancement and an increased proportion of extracellular matrix (33% or more).

Valve Repair: A "Bridge" to Heart Transplant.

Cardiac transplants are limited because of a deficiency of donor organs. Most recipients with severe chronic heart failure are on a waiting list. Therefore, palliative surgical treatment of chronic heart failure is widely used.

[Surgical treatment of bilateral occlusive-stenotic lesions of carotid arteries].

The study included 136 patients with atherosclerotic lesions of carotid arteries allocated to 3 groups depending on the state of contralateral arteries. Group1: patients with stenosis and occlusion of contralateral internal carotid artery (ICA) (n = 31); group 2: patients with bilateral carotid stenosis (n = 62); group 3: patients with unilateral ICA stenosis (n = 43). 20, 54 and 34 patients of these groups respectively were operated.

[The use of low-molecular heparins in reconstructive surgery of ascending aortic aneurysms].

This paper analyzes the results of the use of enoxaparin for anticoagulant therapy in reconstructions on the ascending aorta (AA) as compared to unfractionated heparin applied previously in the control group. Between 1986 and 2003 a total of 30 patients with AA aneurysms were operated on at the clinic. Insufficiency of the aortic valve with degree II-III regurgitation was present in 25 (83.