Publications by authors named "A O Sawamura"
Background: This study aimed to determine the status of in-hospital cardiac rehabilitation (CR) and hospital-associated disability (HAD) for patients with acute myocardial infarction (AMI) aged >80 years.
Methods And Results: This study involved the Japanese Registry of All Cardiac and Vascular Diseases and the Diagnosis Procedure Combination databases, and included patients who were hospitalized with AMI from April 2014 to March 2021. Patients were categorized by the daily amount of CR: NA, not applicable; Low, 20-30 min; Moderate, 30-40 min; and High, >40 min.
Combinations of cysteine, ascorbic acid, and pyridoxine are frequently used in oral formulations. Although there have been many reports on the efficacy of each of these ingredients, little information is known about their combined effects on skin cells. The purpose of this study was to evaluate the combined effects of cysteine, ascorbic acid, and pyridoxine, as well as the effect of adding α-lipoic acid, on skin cells.
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- Hospital-associated disability (HAD) is a decline in the ability to perform daily activities during hospitalization, particularly affecting older adults. This study investigates how inpatient cardiac rehabilitation (CR) impacts the development of HAD in older patients undergoing transcatheter aortic valve implantation (TAVI).
- Out of nearly 20,000 patients studied, those who participated in CR had a significantly lower prevalence of HAD (8.8%) compared to non-participants (14.2%), suggesting CR is beneficial in preventing this decline.
- However, the positive effects were less pronounced in patients with low body mass index (BMI) or lower Barthel Index (BI) scores at admission, indicating some patients might not benefit as much from CR.
Article Synopsis
- The study explores how regional factors affect participation in cardiac rehabilitation (CR) and includes a large cohort of 2.7 million inpatients in Japan from 2012 to 2021.
- It categorizes hospitals into No-CR, High-CR, and Low-CR based on participation rates, finding that High-CR hospitals tend to have smaller service areas, more physicians per population, higher temperatures, and fewer primary industry workers.
- Key regional characteristics influencing High-CR hospitals include a lower consumer price index and a tendency for a younger population, thus highlighting the importance of local economic and demographic factors in CR participation.
The incidence of cerebral infarction triggered by abnormal glucose tolerance has increased; however, the relationship between glucose concentration in the brain and the detailed mechanism of post ischemic cell death remains unclear. Nicotinamide phosphoribosyltransferase (NAMPT), an adipocytokine, is the rate-limiting enzyme for NAD synthesis in the salvage pathway. Although NAMPT activation prevents neuronal injury, the relationship between NAMPT activity, glucose metabolism disorders, and cerebral ischemia-induced neuronal cell death is unknown.
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