Patient's psychological experiences during and after recovery from COVID-19 pandemic: a phenomenological study in Pakistan.

Background: COVID-19 is a transmissible and infectious disease with symptoms similar to pneumonia, ranging from moderate to severe. This study investigated the psychological experiences of patients both during their illness and after their recovery.

Methods: The study employed purposive sampling and semi-structured interviews to gather insights from 13 COVID-19 survivors (7 women and 6 men).

Algal organic matter alters protistan community structure and assembly processes in coastal sediments.

Diatom blooms are a global ecological perturbation that releases algal organic matter (AOM), significantly affecting coastal ecosystems by altering microbial community dynamics. AOM, derived from algal cell lysis, may serve as a nutrient source influencing protistan communities. However, the effects of AOM on protistan ecology, including the community structure and assembly processes, remain largely unexplored in coastal sediments.

Bioinformatics and immunoinformatics approaches in the design of a multi-epitope vaccine targeting CTLA-4 for melanoma treatment.

Melanoma, a highly aggressive skin cancer, remains a significant cause of mortality despite advancements in therapeutic strategies. There is an urgent demand for developing vaccines that can elicit strong and comprehensive immune responses against this malignancy. Achieving this goal is crucial to enhance the efficacy of immunological defense mechanisms in combating this disease.

Box-Behnken Based Furosemide-Nanostructured Lipid Carriers (NLCs) Delivery System for Improving Oral Bioavailability.

Objective: The fabrication of furosemide (FSM) with enhanced oral bioavailability and encapsulation was achieved using a nanostructured lipid carriers (NLCs) drug delivery system.: The uniform drug distribution is a barrier due to its low dose. The lipid-based delivery system was selected based on its poor solubility and permeability, limiting its poor partitioning and solubility in water-based polymeric delivery systems.