Integrons are anti-phage defence libraries in Vibrio parahaemolyticus.

Bacterial genomes have regions known as defence islands that encode diverse systems to protect against phage infection. Although genetic elements that capture and store gene cassettes in Vibrio species, called integrons, are known to play an important role in bacterial adaptation, a role in phage defence had not been defined. Here we combine bioinformatic and molecular techniques to show that the chromosomal integron of Vibrio parahaemolyticus is a hotspot for anti-phage defence genes.

Comprehensive analysis reveals PLK3 as a promising immune target and prognostic indicator in glioma.

Background: PLK3, which played an important role in cell cycle progression and stress response, was identified as highly expressed in various carcinomas. However, the functions, molecular characteristics, and prognostic value of PLK3 in glioma remained unexplored.

Methods: We analyzed PLK3 expression in glioma samples from multiple databases.

[Analysis of the current status of red blood cell transfusion in very preterm infants from Chinese Neonatal Network in 2022].

To analyze the current status of red blood cell transfusion in very preterm infants (VPI) (gestational age at birth <32 weeks) from Chinese Neonatal Network (CHNN) in 2022. This cross-sectional study was based on the CHNN VPI cohort. It included 6 985 VPI admitted to CHNN 89 participating centers within 24 hours after birth in 2022.

Therapeutic evaluation of glycoprotein hormone β5/α2 in reducing obesity and metabolic dysfunctions in genetically obese ob/ob mice.

The escalating obesity epidemic poses serious public health challenges, requiring the development of effective therapeutic strategies. In this study, we aimed to determine if recombinant glycoprotein hormone β5 (GPHB5) protein, particularly in the hybrid form with glycoprotein hormone α2 (GPHA2) (recombinant corticotroph-derived glycoprotein hormone, rCGH), can alleviate obesity in the genetically obese mice, ob/ob. Six-week-old male ob/ob mice were intraperitoneally injected for four weeks with rCGH (10 mg/kg) treatment.

Abnormal stability of dynamic functional architecture in drug-naïve children with attention-deficit/hyperactivity disorder.

Background And Aims: Attention-deficit/hyperactivity disorder (ADHD) is most commonly diagnosed neurodevelopmental disorder in childhood, characterized by developmentally inappropriate inattention and/or hyperactivity/impulsivity symptoms. Static and dynamic functional connectivity (FC) studies have revealed brain dysfunction in ADHD. However, few studies have estimated the stability of dynamic functional architecture of children with ADHD.