Publications by authors named "A O Oyedele"
Dihydrofolate reductase (DHFR), due to its universality and the depth with which it has been studied, is a model system in the study of protein dynamics. Myriad previous works have identified networks of residues in positions near to and remote from the active site that are involved in the dynamics. For example, specific mutations on the Met20 loop in DHFR (N23PP/S148A) are known to disrupt millisecond-time scale motions as well as reduce catalytic activity.
View Article and Find Full Text PDFUnusual presentation of fibroadenoma in the pelvic region - A case report.
Int J Surg Case Rep
November 2024
Article Synopsis
- * A case involved a young woman with a painless swelling on her mons pubis that was initially misdiagnosed as a lipoma but later confirmed to be EBT upon further examination.
- * EBT arises from the incomplete regression of mammary ridges during development, and while it's usually found in the axilla, it's crucial to consider its presence in other areas if swellings are influenced by hormonal changes during puberty, pregnancy, or lactation.
The role of dynamics in enzymatic function is a highly debated topic. Dihydrofolate reductase (DHFR), due to its universality and the depth with which it has been studied, is a model system in this debate. Myriad previous works have identified networks of residues in positions near to and remote from the active site that are involved in dynamics and others that are important for catalysis.
View Article and Find Full Text PDFTime span in literature: 1985-early 2024Natural products play a key role in drug discovery, both as a direct source of drugs and as a starting point for the development of synthetic compounds. Most natural products are not suitable to be used as drugs without further modification due to insufficient activity or poor pharmacokinetic properties. Choosing what modifications to make requires an understanding of the compound's structure-activity relationships.
View Article and Find Full Text PDFIntroduction: Maxillofacial fractures (MFs) are quite common and are managed by oral and maxillofacial surgeons. Despite these interventions, a pre-traumatic facial profile is often not achieved with consequent social and psychologic consequences.
Materials And Methods: Patients with fractures to the middle and lower third of the face that presented within 48 hours and healthy controls (subjects without facial fracture) that were sex- and age-matched with the fracture patients were recruited into the study.