Publications by authors named "A O Osunkoya"
Clear cell adenocarcinoma (CCA) of the urinary tract is a rare malignancy and tumors involving the renal pelvis are notably sparse in the literature, with only 5 other patients reported. We present 5 patients, 4 women, and 1 man, with CCA of the renal pelvis. The age at presentation ranged from 29 to 81 years.
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- Synovial sarcoma (SS) is a rare type of cancer, primarily found in genitourinary tissues, commonly linked to the SS18::SSX gene fusion, and its paratesticular occurrence is extremely uncommon, with only 4 documented cases prior to this study.
- This research details the characteristics and genetic profile of the largest cohort of paratesticular SS patients, analyzing data from 14 individuals aged 15 to 47, all of whom underwent surgical removal of the tumors and some received chemotherapy.
- The findings indicate a generally poor prognosis for paratesticular SS even after aggressive treatment, emphasizing the need for thorough diagnostic methods to differentiate it from similar conditions, and supporting the use of SS18-SS
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- Pure intertubular seminoma (PITS) is a rare type of testicular cancer where seminoma cells are found in testicular interstitium without forming a noticeable mass or diffuse growth, leading to challenges in diagnosis.
- This condition often goes unnoticed and is usually diagnosed incidentally during evaluations for testicular pain, infertility, or other issues, with only a minority of cases presenting with metastasis.
- A study involving 15 patients revealed that the average age at presentation was 29, and common symptoms included undescended testis, testicular pain, and infertility, while most patients had normal serum markers and no visible tumors at the time of diagnosis.
Cabozantinib is an oral multikinase inhibitor approved for treatment in metastatic renal cell carcinoma (RCC). We hypothesized that neoadjuvant cabozantinib could downstage localized tumors, facilitating partial nephrectomy, and facilitating surgery in patients with locally advanced tumors that would require significant adjacent organ resection. We, therefore, conducted a phase 2, single-arm trial of cabozantinib treatment for 12 weeks in 17 patients with locally advanced biopsy-proven non-metastatic clear cell RCC before surgical resection.
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- * The survey received an 85% response rate from 98 uropathologists, revealing strong agreement on distinguishing between luminal and basal UC types, but varied opinions on the importance of certain genetic tests like FGFR3 and TERT promoter mutations.
- * Most uropathologists acknowledged the aggressive nature of tumors with micropapillary features and favored further evaluation and specific molecular testing for aggressive subtypes, indicating a need for improved consensus in UC classification and treatment strategies.