Publications by authors named "A O Olatunji"
Article Synopsis
- Crohn's disease (CD) significantly affects patients' quality of life, and this review assesses the effectiveness and safety of upadacitinib, a JAK inhibitor, in treating it.
- The analysis included seven studies with 1,481 patients, and results showed upadacitinib outperforms placebo in achieving clinical remission and reducing inflammation quickly, often within five to six days.
- While the treatment has a generally acceptable safety profile, with risks like infections and laboratory abnormalities, it presents as a promising option for managing moderate to severe CD, particularly for those who have not responded to other therapies.
Retraction Note: Flavonoid fractions of diosmin and hesperidin mitigate lead acetate-induced biochemical, oxidative stress, and histopathological alterations in Wistar rats.
Toxicol Res
October 2024
[This retracts the article DOI: 10.1007/s43188-020-00084-9.].
View Article and Find Full Text PDFBone tissue engineering (BTE) provides an alternative for addressing bone defects by integrating cells, a scaffold, and bioactive growth factors to stimulate tissue regeneration and repair, resulting in effective bioengineered tissue. This study focuses on repurposing chitosan from blue swimming crab () shell waste as a composite scaffold combined with HAP and COL I to improve biocompatibility, porosity, swelling, and mechanical properties. The composite scaffold demonstrated nearly 60% porosity with diameters ranging from 100-200 μm with an interconnected network that structurally mimics the extracellular matrix.
View Article and Find Full Text PDFAmeliorative potentials of diosmin and hesperidin fractions on chlorpyriphos-induced changes in reproductive hormones, sperm characteristics, and testicular glycogen in male Wistar rats.
Naunyn Schmiedebergs Arch Pharmacol
November 2024
Article Synopsis
- Pesticide exposure, specifically from Chlorpyriphos, causes significant reproductive issues in male rats by damaging their sex organs and reducing hormone levels, sperm quality, and testicular glycogen.
- The study examined the effect of flavonoids (diosmin and hesperidin) on recovering reproductive functions in male Wistar rats after they were exposed to Chlorpyriphos for 60 days.
- Results showed that the rats treated with flavonoids had notably better levels of reproductive hormones, improved sperm parameters, and higher testicular glycogen compared to those treated only with Chlorpyriphos, indicating the potential protective effects of these antioxidant compounds against pesticide toxicity.
Emerging from the shadow of the COVID-19 pandemic, it is time to ground ourselves and retrospectively assess the recent achievements of SEGH over the past years. This editorial serves as a comprehensive report on the progress made in comparison to the aspirations and goals set by the society's board in 2019 (Watts et al., Environ Geochem Health 42:343-347, 2019) (Fig.
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