Multi-regulator of EZH2-PPARs Therapeutic Targets: A Hallmark for Prospective Restoration of Pancreatic Insulin Production and Cancer Dysregulation.

The unexpected rise in cancer and diabetes statistics has been a significant global threat, inciting ongoing research into various biomarkers that can act as innovative therapeutic targets for their management. The recent discovery of how EZH2-PPARs' regulatory function affects the metabolic and signalling pathways contributing to this disease has posed a significant breakthrough, with the synergistic combination of inhibitors like GSK-126 and bezafibrate for treating these diseases. Nonetheless, no findings on other protein biomarkers involved in the associated side effects have been reported.

Serological survey of salmonellosis in grey duiker (Sylvicapra grimmia) in Asejire, Irewole Local Government Area, Osun State, Nigeria.

A serological survey of salmonellosis in grey duiker was carried out in Asejire, Irewole Local Government Area (LGA), Osun State, between August and September, 1996. The sera of 50 animals were screened for antibodies to salmonella flagella (H) and/or somatic (O) antigens. Ten "bushmeat" hawkers/processors were interviewed on their state of health.

Pathobiochemical mechanisms involved in the control of the disease caused by Trypanosoma congolense in African grey duiker (Sylvicapra grimmia).

The course of Trypanosoma congolense infections in African grey duiker (Sylvicapra grimmia) and sheep and goats were studied. Several parameters suggested that the grey duiker was much more resistant to trypanosomosis than sheep and goats. They showed increases in weight during infection, had a much longer pre-patent period, and their peak parasitaemia levels were about 100-fold lower than those of sheep and goats.

Weights and blood profiles of the west African hinge-backed tortoise, Kinixys erosa and the desert tortoise, Gopherus agassizii.

The body weight and blood profile were determined in the adult wild West African hinge-backed tortoise, Kinixys erosa and the adult wild desert tortoise, Gopherus agassizii kept under identical environmental conditions. A comparison between sexes showed the male K. erosa had significantly higher packed cell volume and haemoglobin concentration and lower body weight and plasma alkaline phosphatase values than the female, while no significant sex differences appeared in these parameters in G.

Haematological changes in ewes experimentally infected with Trypanosoma brucei.

Changes in the haematological values were studied in West African Dwarf ewes infected with Trypanosoma brucei. This disease was characterized by a normocytic normochromic anaemia in the acute phase and a severe macrocytosis during the chronicity. The observed changes suggest inadequate erythropoiesis in the acute phase while the chronic phase had a superior but still inadequate erythropoietic response with persistent anaemia.