Publications by authors named "A O Kosachenko"
Article Synopsis
- Scientists did a big survey with over 59,000 people from 63 countries to understand how people think about climate change!
- They tested different ways to encourage people to believe in climate change and support actions to help the environment!
- The study includes lots of information and data that can help others learn more about what influences people's actions on climate change around the world!
Previously, we showed the antitumor activity of the new NOS/PDK inhibitor T1084 (1-isobutanoyl-2-isopropylisothiourea dichloroacetate). The present study included an assessment of in vitro cytotoxicity against human malignant and normal cells according to the MTT-test and in vivo antitumor effects in solid tumor models in comparison with precursor compounds T1023 (NOS inhibitor; 1-isobutanoyl-2-isopropylisothiourea hydrobromide) and Na-DCA (PDK inhibitor; sodium dichloroacetate), using morphological, histological, and immunohistochemical methods. The effects of T1084 and T1023 on the in vitro survival of normal (MRC-5) and most malignant cells (A375, MFC-7, K562, OAW42, and PC-3) were similar and quantitatively equal.
View Article and Find Full Text PDFProton therapy can treat tumors located in radiation-sensitive tissues. This article demonstrates the possibility of enhancing the proton therapy with targeted gold nanoparticles that selectively recognize tumor cells. Au-PEG nanoparticles at concentrations above 25 mg/L and 4 Gy proton dose caused complete death of EMT6/P cells in vitro.
View Article and Find Full Text PDFArticle Synopsis
- The study explored the effectiveness of combining local proton irradiation with intra-tumoral injections of two types of bismuth nanoparticles (one coated with Pluronic-F127 and the other with Silane-PEG).
- Both types of nanoparticles significantly enhanced the antitumor effects of proton therapy when injected directly into the tumor, with greater effects observed at higher doses of nanoparticles and radiation.
- These findings suggest a potential new approach for improving treatments for malignant tumors by using nanoparticles to increase the efficacy of radiation therapy.
Article Synopsis
- Effective global behavior change is crucial for reducing climate change, but it's unclear which strategies motivate people to shift their beliefs and actions.
- A study tested 11 interventions on nearly 60,000 participants across 63 countries, finding small effectiveness primarily among non-skeptics and varied results across different outcomes.
- Key results showed that reducing psychological distance strengthened beliefs, writing a letter to a future generation increased policy support, and inducing negative emotions encouraged information sharing, but no strategy successfully boosted tree-planting efforts.