Age effects on autism heritability and etiological stability of autistic traits.

Background: Autism and autistic traits onset in childhood but persist into adulthood. Little is known about how genetic and environmental factors influence autism and autistic traits into adulthood. We aimed to determine age effects on the heritability of clinically diagnosed autism and the etiological stability of autistic traits from childhood to adulthood using twin methods.

Association between cumulative psychosocial adversity in the family and ADHD and autism: a family-based cohort study.

Cumulative exposure to psychosocial adversity at an early age has been shown to be a risk factor for attention-deficit hyperactivity disorder (ADHD) and autism that often co-occur. However, it is not clear if this association reflects a causal effect or familial confounding. We aimed to assess whether cumulative psychosocial adversity in the family increases the risk for ADHD and autism in offspring while accounting for unmeasured familial confounding.

Sex Differences in Mental Health Problems and Psychiatric Hospitalization in Autistic Young Adults.

Importance: Psychiatric disorders are common among autistic children and adults. Little is known about sex differences in psychiatric disorders and hospitalization in early adulthood.

Objective: To examine sex differences in psychiatric diagnoses and hospitalizations in autistic compared with nonautistic young adults.

[ASSOCIATION OF CERTAIN SINGLE NUCLEOTIDE POLYMORPHISM GENES OF APOPTOSIS SYSTEM WITH A RISK OF DEVELOPMENT OF COLORECTAL CANCER IN RUSSIAN POPULATION].

Aim: Study the effect of single nucleotide polymorphism genes TP53 (rs1042522, rs1800371), CDKN2A (rs3731217, rs3088440) and MDM2 (rs2279744) on the risk of development of color- ectal cancer (CRC) in population of Perm Region.

Materials And Methods: Case group con- sisted of 198 patients with histologically verified CRC, control group - 205 individuals with CRC excluded by results of colonoscopy. DNA genotyping, obtained from leukocytes of venous blood ofthe studied individuals; was carried out by PCRwith electrophoretic detection of results.