Publications by authors named "A O Eifan"
Background: Allergen immunotherapy (AIT) is a well-established disease-modifying therapy for allergic rhinitis, yet the fundamental mechanisms underlying its clinical effect remain inadequately understood. Gauging Response in Allergic Rhinitis to Sublingual and Subcutaneous Immunotherapy was a randomized, double-blind, placebo-controlled trial of individuals allergic to timothy grass who received 2 years of placebo (n = 30), subcutaneous immunotherapy (SCIT) (n = 27), or sublingual immunotherapy (SLIT) (n = 27) and were then followed for 1 additional year.
Objective: We used yearly biospecimens from the Gauging Response in Allergic Rhinitis to Sublingual and Subcutaneous Immunotherapy study to identify molecular mechanisms of response.
Introduction: There is no detailed comparison of allergen-specific immunoglobulin responses following sublingual immunotherapy (SLIT) and subcutaneous immunotherapy (SCIT).
Objective: We sought to compare nasal and systemic timothy grass pollen (TGP)-specific antibody responses during 2 years of SCIT and SLIT and 1 year after treatment discontinuation in a double-blind, double-dummy, placebo-controlled trial.
Methods: Nasal fluid and serum were obtained yearly (per-protocol population, n = 84).
Background: Allergen-specific immunotherapy is a disease-modifying treatment that induces long-term T-cell tolerance.
Objective: We sought to evaluate the role of circulating CXCR5PD-1 T follicular helper (cT) and T follicular regulatory (T) cells following grass pollen subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) and the accompanying changes in their chromatin landscape.
Methods: Phenotype and function of cT cells were initially evaluated in the grass pollen-allergic (GPA) group (n = 28) and nonatopic healthy controls (NAC, n = 13) by mathematical algorithms developed to manage high-dimensional data and cell culture, respectively.
Article Synopsis
- The study investigates the link between allergic inflammation and airway remodelling in seasonal allergic rhinitis (AR) using a new nasal allergen challenge model.
- Twelve patients with moderate-severe AR underwent two sets of challenges (diluent followed by grass pollen) while their nasal symptoms and cytokine levels were monitored, along with nasal biopsies to assess inflammation.
- Results showed significant increases in nasal tissue eosinophils and IL-5 levels after allergen exposure, but no notable changes in indicators of airway remodelling compared to healthy controls.