Elaboration of the preliminary Rheumatoid Arthritis Impact of Disease (RAID) score: a EULAR initiative.

Background: Current response criteria in rheumatoid arthritis (RA) usually assess only three patient-reported outcomes (PROs): pain, functional disability and patient global assessment. Other important PROs such as fatigue are not included.

Objective: To elaborate a patient-derived composite response index for use in clinical trials in RA, the RA Impact of Disease (RAID) score.

[Spontaneous synchronous discharges in hippocampal slices. Simulation and experiment].

Chaotic oscillations of extracellular potential of field-type nerve tissues are simulated by a 2D coupled map lattice. These tissues, say, the fields of the hippocampus, are represented by neural mass sheets consisting of current sources. The relationship between the source-sink ensembles and the extracellular field potential at each discrete instant of time t = 1, 2, .

A model of adaptive visual processes of primary image processing.

A computer model of adaptive segmentation of two-dimensional visual objects was developed, based on neurophysiological and psychophysiological principles. The model imitates several stages of visual information processing. At the first stage, a preliminary assessment of the image is performed using a brightness pattern analyzer.

[The model of adaptive primary image processing].

A computer model of adaptive segmentation of the 2D visual objects was developed. Primary image descriptions are realised via spatial frequency filters and feature detectors performing as self-organised mechanisms. Simulation of the control processes related to attention, lateral, frequency-selective and cross-orientation inhibition, determines the adaptive image processing.

Coupled map lattice simulation of epileptogenesis in hippocampal slices.

Bioelectric activity of a nervous tissue and its synchronization with formatting epileptiform bursts are simulated by a coupled map lattice. The functional units of the map located in the lattice sites represent neural masses which consist of current sources and sinks. The sources lead to depolarization of neurons, and sinks provide hyperpolarization.