Publications by authors named "A O'connor"

Background: Falls are frequently reported within the HSE. The Irish Longitudinal Study on Ageing(TILDA) found that 40% of over 50 s experience a fall in a two year period, with 20% requiring hospital attendance (1). It has been estimated that the cost of injuries related to falls in older people will increase exponentially over the coming years (2).

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Article Synopsis
  • DMSC-derived extracellular vesicles (DMSC_EV) were shown to enhance DMSC proliferation and mobility on specific growth surfaces, particularly s-dAM.
  • DMSC attachment varied based on the substrate, with increased attachment observed on decellularized surfaces and Matrigel when EVs were included.
  • The study highlights that combining in vitro EVs and extracellular matrix (ECM) components can optimize the expansion and therapeutic potential of mesenchymal stem cells (MSCs) for various applications.
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Despite a growing awareness that primary care is essential to an accessible, equitable, high-quality, cost-effective health care system, family medicine research remains woefully underdeveloped. The increased focus of both state and federal policy makers on primary care payment and care delivery models presents an opportunity for family medicine to redefine itself as an academically rigorous discipline at the forefront of generating evidence that improves patient care and population health while reducing costs. In a critical review of the literature, we identified five themes-leadership, funding, resources, team science, and departmental culture-that are integral to family medicine departments seeking to grow and expand their research capacity.

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Introduction: Anal acoustic reflectometry (AAR), a novel test of anal sphincter function, was shown to predict a successful trial phase of sacral neuromodulation (SNM) for fecal incontinence. This follow-up study aims to explore if AAR can also predict short- and long-term SNM outcomes at less than and more than 5 y, respectively.

Methods: Outcome data were reviewed from a prospectively managed database.

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