Dissection of the MYCN locus in Feingold syndrome and isolated oesophageal atresia.

Feingold syndrome (FS) is a syndromic microcephaly entity for which MYCN is the major disease-causing gene. We studied the expression pattern of MYCN at different stages of human embryonic development and collected a series of 17 FS and 12 isolated oesophageal atresia (IOA) cases. An MYCN gene deletion/mutation was identified in 47% of FS cases exclusively.

Post-antibiotic effects of RP 59500 with Staphylococcus aureus.

The post-antibiotic effect (PAE) of the semisynthetic streptogramin RP 59500 was evaluated with four clinical isolates of Staphylococcus aureus (two strains susceptible to methicillin and to the macrolide-lincosamide-streptogramin B (MLSB) group and two strains resistant to these drugs). The PAE was defined as the time required for either the viable counts to increase by one log10 or for bacteria to regain their maximal rate of growth. Similar results were obtained regardless of which definition was used.