Publications by authors named "A Noorafshan"
Understanding the intricate molecular mechanisms governing aryl hydrocarbon receptor (AHR) and Wnt/β-Catenin pathways crosstalk is of paramount importance for elucidating normal development. We investigated the repercussions of aberrant activation of these signaling pathways on kidney development. HEK-293 cells were subjected to AHR and Wnt activators and inhibitors for 3 and 24 h.
View Article and Find Full Text PDFBackground: L. (Kasni) distillate is widely used in Eastern countries as a safe herbal drink to improve male fertility. However, the potential effects on fertility parameters and possible adverse effects have not been studied experimentally.
View Article and Find Full Text PDFArticle Synopsis
- The paraventricular nucleus of the hypothalamus (PVH) is crucial for regulating sleep and stress, and chronic REM sleep deprivation (CSD) over 21 days negatively affects its structure and function in male rats.
- In the study, rats were divided into groups receiving either curcumin or a control treatment, and their PVH was analyzed for volume, cell count, and neuron health using various scientific methods.
- Results showed that CSD led to significant decreases in PVH volume and cell numbers, along with increased neuron death, but curcumin treatment was effective in reversing these changes and restoring normal neuron arrangement.
Purpose: We aimed to assess the effects of a cocktail comprising three specific anti- HER2 scFvs on breast tumor formation in a xenograft mouse model and to evaluate quantitative changes in the tumor using stereological analysis.
Methods: Three specific anti-HER2 phage antibodies were produced from a scFv-library using phage display technology. The cell binding capacities of the antibodies were assessed via FACS analysis.
Objective: Sleep deprivation (SD) is a common problem in today's stressful lifestyle and have physiological consequences, including reproductive dysfunction and infertility. As an antioxidant, olive oil may be effective in reducing testicular and spermatological damage by decreasing the production of free radicals.
Methods: This study investigated the effects of olive oil on sperm quality and testicular structure using stereological methods to assess rats with SD.