Tetrazole Is a Novel Zinc Binder Chemotype for Carbonic Anhydrase Inhibition.

The tetrazole group is here proposed as a zinc-binding warhead for the inhibition of the metalloenzyme carbonic anhydrases. A set of synthesized derivatives incorporating the tetrazole moiety were evaluated as inhibitors against a panel of human isoforms, exhibiting values spanning between the submicromolar and low-to-medium micromolar ranges (0.62-19.

Cybervictimization and Online Sexual Harassment: Prevalence, Association, and Predictors.

Background: The daily and massive use of the Internet and social media by adolescents has led to increased interest and attention to prevalence rates, risk factors, and potential consequences of different forms of online victimization. This study aims to examine the possible associations between cybervictimization and online sexual harassment among 697 Italian adolescents (M = 15.17; SD = 0.

Putting situational affordances in an intervention context: How the interaction between personality and intervention situations can help us explain differential intervention responses.

We propose a framework in which interventions are described as situations affording the expression of certain personality traits to provide a systematic understanding of differential intervention response by personality traits. The goal of the present paper is twofold: 1) elaborate on the proposed framework, and 2) provide an initial test of this framework. We empirically tested this framework using data from a Randomized Controlled Trial (N = 176) that examined a smartphone-based intervention aimed at increasing future-oriented thinking and behavior, and assessed HEXACO personality traits.

Exploring aliphatic sulfonamides as multiclass inhibitors of the carbonic anhydrases from the pathogen bacterium Vibrio cholerae.

This study investigates aliphatic sulfonamide derivatives as inhibitors of the α-, β-, and γ-class carbonic anhydrase (CA) isoforms from Vibrio cholerae (VchCAs). A series of 26 compounds bearing a triazole linker and urea- or ether-based tails were described and evaluated for their inhibitory action using a stopped-flow CO hydrase technique. These inhibitors demonstrated a preferential efficacy against VchCAβ.

Superacid-Synthesized Fluorinated Diamines Act as Selective hCA IV Inhibitors.

Carbonic anhydrase (CA) IV is a membrane-bound enzyme involved in important physio-pathological processes, such as excitation-contraction coupling in heart muscle, central nervous system (CNS) extracellular buffering, and mediation of inflammatory response after stroke. Known since the mid-1980s, this isoform is still largely unexplored when compared to other isoforms, mostly for the current lack of inhibitors targeting selectively this isoform. The discovery of selective CA IV inhibitors is thus largely awaited.