Publications by authors named "A Nishizono"
The variants of concern (VOCs) of SARS-CoV-2 have exhibited different phenotypic characteristics in clinical settings which are yet to be fully explored. This study aimed to characterize the viral replication features of major VOCs of SARS-CoV-2 and their association with pathogenicity. The Alpha, Delta, and Omicron variants of SARS-CoV-2 isolated from the COVID-19 patients in Japan were propagated in VeroE6/TMPRSS2 cells.
View Article and Find Full Text PDFArticle Synopsis
- Rabies is a highly infectious viral disease that mainly affects the central nervous system, is often transmitted by mammals like dogs, has a long incubation period, and carries a nearly 100% mortality rate with no effective treatment available.
- Japan eradicated rabies in 1957 through stringent vaccination measures, and the country maintains strict controls that surpass international standards, despite experiencing a few imported cases since then.
- Recent events, such as the quarantine of evacuee dogs from Ukraine and a dog bite incident in Gunma Prefecture that raised concerns about rabies, highlight ongoing vigilance and the need for effective rabies control and management strategies both in Japan and globally.
Objectives: Nipah virus (NiV), a bat-borne zoonotic pathogen, poses persistent threats to global public health due to severe clinical manifestation and high case fatality rate (CFR). A critical examination of NiV outbreaks is essential for refining strategies and mitigating the impact of future infections. In this study, we provide a concise update on global NiV outbreaks that occurred during the past 25 years.
View Article and Find Full Text PDFIntroduction: A blood culture (BC) test is vital for diagnosing bacteremia in clinical practice. Although incubation time varies among automated BC systems, 4-5 days is deemed to be sufficient time for the BD BACTEC FX blood culture system. This study compared the clinical and microbiological characteristics of true-positive BC samples on day 5 with those within 4 days to reduce missed true bacteremia cases.
View Article and Find Full Text PDFObjectives: Dengue, a life-threatening disease caused by the mosquito-borne dengue virus, has become a severe problem in recent years in Bangladesh, a South Asian country. In this study, we have critically analyzed the factors contributing to the escalation of the dengue burden in recent years in Bangladesh and discussed the strategies for effective control.
Design: This retrospective observational study analyzed the dengue data collected from the five most dengue-affected countries (Bangladesh, Brazil, Mexico, Peru, and the Philippines) from 2019 to 2023.