Publications by authors named "A Nishio"
A 55-year-old man with tuberous sclerosis complex (TSC) was diagnosed with left renal angiomyolipoma (AML), a group of perivascular epithelioid cell tumors called PEComas. He had received the mTOR inhibitor everolimus, which resulted in a complete response. However, a left renal mass relapsed in two years, followed by the occurrence of a hepatic mass five months later.
View Article and Find Full Text PDFIntroduction: The COVID-19 pandemic has severely impacted the health and education of learners globally. However, there is a lack of information on enablers and barriers to the implementation of comprehensive school health policies during the pandemic.
Methods: This study utilized a case study design, and was conducted in the Division of City Schools of Navotas.
Intrahepatic Exhausted Antiviral Immunity in an Immunocompetent Mouse Model of Chronic Hepatitis B.
Cell Mol Gastroenterol Hepatol
December 2024
Article Synopsis
- Researchers developed a new mouse model to study chronic hepatitis B (CHB) by delivering the HBV genome and a key enzyme, allowing for detailed immune profiling in a lab setting.
- The CHB mice showed ongoing HBV infection and had signs of exhausted immune cells, with treatments using IFNα and a TLR7 agonist leading to viral suppression and immune enhancement.
- This study's mouse model mimics immune exhaustion seen in CHB patients and suggests that targeted treatments could help restore immune function against HBV.
Aim: Patients with chronic hepatitis B (CHB) remain at risk for hepatocellular carcinoma (HCC) even with nucleos(t)ide analog therapy. We evaluated risk factors for HCC development, including serum hepatitis B virus (HBV) RNA, hepatitis B core-related antigen level, and growth differentiation factor 15 (GDF15) level, a predictor of HCC development in patients with chronic hepatitis C.
Methods: We collected clinical data and stored serum from CHB patients without a history of HCC who were receiving nucleos(t)ide analog treatment for more than 1 year and whose HBV DNA level was less than 3.
Background: Given the need for a simple tool to evaluate mental healthcare provision at the local level, we compared the duration of untreated mental illness (DUM) and duration of untreated psychosis (DUP) between rural and urban areas in Cambodia, and Cambodia's DUP was also compared with that of other countries.
Methods: DUM and background data were obtained at the first consultation from 940 participants in Phnom Penh (PP), the capital city, and Siem Reap province (SR) in 2016-2017. DUP data were obtained from DUM by excluding individuals with nonpsychotic mental illnesses (e.