Exploring the possible mitoprotective and neuroprotective potency of thymoquinone, betanin, and vitamin D against cytarabine-induced mitochondrial impairment and neurotoxicity in rats' brain.

It has been suggested that cytarabine (Ara-C) induces toxicity via mitochondrial dysfunction and oxidative stress. Therefore, we hypothesized that mitochondrial protective agents and antioxidants can reduce cytarabine-induced neurotoxicity. For this purpose, 48 male Wistar rats were assigned into eight equal groups include control group, Ara-C (70 mg/kg, i.

Evaluation of nuclear reaction cross sections for optimization of production of the non-standard positron emitting radionuclide Nb using proton induced reactions on Zr target.

Niobium-90 radionuclide is one of the promising candidates for the positron emission tomography (PET) technique. In this study, Nb excitation functions via Zr(p,n) and Zr(p,xn) reactions were computed using the TALYS-1.95 code based on phenomenological and microscopic level density models.

Nuclear model calculations on the production of auger electron emitter In: As a theranostic radionuclide.

The main goal of this study is the production investigation of the In as a diagnostic and mighty radionuclide in nuclear medicine especially in the Single Photon Emission Computed Tomography (SPECT) technique. Excitation functions based on four main phenomenological level density models were evaluated for the induced reactions; namely, Ag(α,2n), Cd(d,n),Cd(p,n),Cd(p,2n),Cd(p,xn) and Cd(d,xn) using the TALYS-1.8 and EMPIRE-3.

Overview and evaluation of different nuclear level density models for the I radionuclide production.

The I radionuclide (T = 13.22 h, β+ = 100%) is one of the most potent gamma emitters for nuclear medicine. In this study, the cyclotron production of this radionuclide via different nuclear reactions namely, the Sb(α,2n), Te(d,n), Te(p,n), Te(p,2n), Xe(p,2n), I(p,5n) and I(d,6n) were investigated.