Hydrodynamic Radii of Intrinsically Disordered Proteins: Fast Prediction by Minimum Dissipation Approximation and Experimental Validation.

The diffusion coefficients of globular and fully unfolded proteins can be predicted with high accuracy solely from their mass or chain length. However, this approach fails for intrinsically disordered proteins (IDPs) containing structural domains. We propose a rapid predictive methodology for estimating the diffusion coefficients of IDPs.

Diversity of hydrodynamic radii of intrinsically disordered proteins.

Intrinsically disordered proteins (IDPs) form an important class of biomolecules regulating biological processes in higher organisms. The lack of a fixed spatial structure facilitates them to perform their regulatory functions and allows the efficiency of biochemical reactions to be controlled by temperature and the cellular environment. From the biophysical point of view, IDPs are biopolymers with a broad configuration state space and their actual conformation depends on non-covalent interactions of its amino acid side chain groups at given temperature and chemical conditions.

Masquerade of Polish Society-Psychological Determinants of COVID-19 Precautionary Behaviors.

The risk of contracting COVID-19 was a very specific situation of uncertainty and ambi-guity, and of course, cognitively interesting for psychologists studying the determinants of behaviors of different personality types. In this study, we set our sights on trying to find a correlation between adherence to wearing masks and receiving vaccinations and having certain character traits that we thought might influence preventive behavior or not. We focused on the Dark Triad-psychopathy, Machiavellianism and narcissism-as well as social approval and the need for cognition closure, as these traits have previously been linked to heightened conspiracy mentalities.

Regiospecific O → N Acyl Migration as a Methodology to Access l-Altropyranosides with an 2,4-Differentiation.

Pseudaminic acid and its biosynthetic altropyranoside precursors are bacterial components currently being investigated toward novel antibacterial strategies. One structural feature associated with these naturally occurring flagellar carbohydrates is the different -acylation patterns on the two amido functionalities, posing a synthetic challenge. A new one-pot methodology is reported and a scope of diverse 2/4-differentiated analogs are presented via a Staudinger reduction-mediated regiospecific O3 → N4 acyl migration, followed by an autonomous 2-acylation.