Publications by authors named "A Nicholl"
Article Synopsis
- The audit aimed to assess and improve the completeness and accuracy of the National Joint Registry (NJR) dataset specifically for elbow arthroplasty surgeries.
- In a two-phase approach, Phase 1 compared NJR data with NHS England Hospital Episode Statistics (HES), identifying thousands of unmatched and inaccurate records, particularly for radial head arthroplasties (RHAs).
- Phase 2 involved collaboration among 142 NHS hospitals to correct and update records, resulting in an improved completeness of the NJR dataset from 63% to 93% and accuracy from 94% to 98%.
Background: Limited evidence supports the common public health guideline that children >2 y of age should consume dairy with reduced fat content.
Objectives: We aimed to investigate the effects of whole-fat compared with reduced-fat dairy intake on measures of adiposity and biomarkers of cardiometabolic risk in healthy 4- to 6-y-old children.
Methods: The Milky Way Study enrolled 49 children (mean ± SD age: 5.
Background: There is a growing momentum in paediatric ethics to develop respectful research and healthcare protocols. We developed, tested and refined our 'Respectful Approach to Child-centred Healthcare' (ReACH), to underpin respectful participant interactions in a clinical trial.
Objective: To determine whether a ReACH-based approach is acceptable to children and parents, and effective in obtaining compliance with common healthcare assessments in a clinical trial of healthy 4-6-year-old children.
Importance: Micro-dystrophin gene transfer shows promise for treating patients with Duchenne muscular dystrophy (DMD) using recombinant adeno-associated virus serotype rh74 (rAAVrh74) and codon-optimized human micro-dystrophin driven by a skeletal and cardiac muscle-specific promoter with enhanced cardiac expression (MHCK7).
Objective: To identify the 1-year safety and tolerability of intravenous rAAVrh74.MHCK7.
Laser ablation multi-collector inductively coupled plasma mass spectrometry (LA-MC-ICP-MS) was applied to the detailed investigation of the uranium (U) isotopic composition (U, U, U, and U) of five contaminated scrap metal samples found within the European Union. Pressed pellets of the two certified U isotopic reference materials CRM U-020 and CRM U-030 were included in the measurement protocol for mass bias correction, calculation of the ion counter gains and for quality assurance. Since the investigated samples had low U content (0.
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