Endothelial Dysfunction and Liver Cirrhosis: Unraveling of a Complex Relationship.

Endothelial dysfunction (ED) is the in the background of multiple metabolic diseases and a key process in liver disease progression and cirrhosis decompensation. ED affects liver sinusoidal endothelial cells (LSECs) in response to different damaging agents, causing their progressive dedifferentiation, unavoidably associated with an increase in intrahepatic resistance that leads to portal hypertension and hyperdynamic circulation with increased cardiac output and low peripheral artery resistance. These changes are driven by a continuous interplay between different hepatic cell types, invariably leading to increased reactive oxygen species (ROS) formation, increased release of pro-inflammatory cytokines and chemokines, and reduced nitric oxide (NO) bioavailability, with a subsequent loss of proper vascular tone regulation and fibrosis development.

Peltigera lichens as sources of uncharacterized cultured basidiomycete yeasts.

Lichens represent one of the most successful examples of symbiosis. They are constituted by the association between a dominant fungus (i.e.

Draft genome sequences of two biocontrol agents isolated from the maize phyllosphere strain EM-A7 and strain EM-A8.

In the present study, the genomes of EM-A7 and EM-A8 were sequenced and annotated. The Illumina sequencing platform (NovaSeq PE150) was used to sequence the genomic DNA. There were 6 277 054 raw reads for EM-A7, with a Q20 of 97.

Effects of different light wavelengths on Bacillus subtilis and Bacillus velezensis, two biocontrol agents isolated from the maize phyllosphere.

In previous studies, two strains isolated from the maize phyllosphere were identified as Bacillus subtilis (EM-A7) and Bacillus velezensis (EM-A8) and selected as potential biocontrol agents against Exserohilum turcicum. This study aimed to assess the ability of EM-A7 and EM-A8 to form biofilm and have antagonistic activity under varying light conditions. LED sources were custom-designed so that each corresponded to a given spectrum at a specific photosynthetically active photon flux density.