Update on the Use of Nanocarriers and Drug Delivery Systems and Future Directions in Cervical Cancer.

Cervical cancer represents a major health problem among females due to its increased mortality rate. The conventional therapies are very aggressive and unsatisfactory when it comes to survival rate, especially in terminal stages, which requires the development of new treatment alternatives. With the use of nanotechnology, various chemotherapeutic drugs can be transported via nanocarriers directly to cervical cancerous cells, thus skipping the hepatic first-pass effect and decreasing the rate of chemotherapy side effects.

Impact of the Liquid Crystal Order of Poly(azomethine-sulfone)s on the Semiconducting Properties.

Organic semiconductors are an attractive class of materials with large application in various fields, from optoelectronics to biomedicine. Usually, organic semiconductors have low electrical conductivity, and different routes towards improving said conductivity are being investigated. One such method is to increase their ordering degree, which not only improves electrical conduction but promotes cell growth, adhesion, and proliferation at the polymer-tissue interface.

Excessive Primary Postpartum Hemorrhage.

The diagnosis and treatment of excessive bleeding within the first 24 hours after delivery and its main causes, namely uterine atony, retained placental fragments, vascular lesions by local tissue rupture, and blood clotting disorder are presented. Of great interest is the iconography, which is suggestive and original.

Basic aspects in selecting a suitable transgenic rodent model for Alzheimer's disease.

Due to Alzheimer's disease (AD) great aggressiveness, many worldwide health associations began to globalize research efforts in order to find a suitable treatment and to clarify once and for all its controversial aetiology. Moreover, the animal modelling research is one of the best tools to evaluate molecular mechanisms and to correlate them with clinical features and behaviours. However, in order to provide valuable scientific data correlated to low error sources, a rigorous algorithm of selecting the proper animal model for testing is required.

BRCA1 5382insC founder mutation has not a significative recurrent presence in Northeastern Romanian cancer patients.

Developed two decades ago, oncogenetic medical practice mainly concern breast, ovarian and colorectal cancers, and is targeting the hereditary risk factor, the only one that shows positive predictive value justifying the molecular diagnosis. Screening for BRCA1 and BRCA2 gene mutations is standard practice today for hereditary breast and ovarian cancer (HBOC) families in developed countries, offering the possibility of medical follow-up. The gold standard for molecular diagnosis is Sanger sequencing of all exons and exon-intron boundaries, which is expensive and time consuming.