Unusual cutaneous carcinoma with features of small cell (oat cell-like) and squamous cell carcinomas. A variant of malignant Merkel cell neoplasm.

Three unusual primary neoplasms in the skin that occurred in elderly patients (64, 77, and 69 years of age) are presented. Two histologic components were found in each of the three neoplasms, one being small cell or oat cell-like carcinoma and the other squamous cell carcinoma. Study by electron microscopy revealed neurosecretory granules, though few, in the small cell component.

Prospective surveillance by rectal biopsy following ileorectal anastomosis for inflammatory disease.

A prospective study was designed to evaluate multiple rectal biopsy examinations for dysplasia in 34 patients who had ileorectal anastomosis performed, following colectomy for inflammatory bowel disease. Although all but eight patients had persistent inflammatory activity on histologic examination, only one patient who demonstrated villous transformation of the mucosa clinically, showed carcinoma in situ in the excised rectal specimen. A protocol for surveillance of preserved rectums in inflammatory bowel disease is offered.

Carcinosarcoma of the uterine cervix: a light and electron microscopic study.

A case of carcinosarcoma of the uterine cervix is presented. Light microscopic and ultrastructural features of the tumor are described. While the epithelial component had the appearance of a carcinoma arising from endocervical epithelium, the stromal component was composed of malignant smooth muscle cells together with some cells having the charactristics of malignant fibroblasts.

Lymphomatoid papulosis. Ultrastructural study with demonstration of intranuclear and intracytoplasmic viruslike particles.

Transmission electron microscopic study of the bizarre infiltrating cells from a case of lymphomatoid papulosis reveals intranuclear and intracytoplasmic virus-like particles. These cells have large nuclei with multiple nucleoli, scant to moderate profiles of rough endoplasmic reticulum, mitochondria and a variable number of lysosomes. It is suggested that these abnormal cells are macrophages showing viral cytopathogenic effects.