Publications by authors named "A Nastase"
Herein, we report progress toward a metabotropic glutamate receptor subtype 1 (mGlu) positive allosteric modulator (PAM) clinical candidate and the discovery of VU6024578/BI02982816. From a weak high-throughput screening hit (VU0538160, EC > 10 μM, 71% Glu), optimization efforts improved functional potency over 185-fold to deliver the selective (inactive on mGlu) and CNS penetrant (rat K = 0.99, K = 0.
View Article and Find Full Text PDFArticle Synopsis
- Lung carcinoids (L-CDs) are rare neuroendocrine tumors more common in women and categorized into typical (TCs) and atypical carcinoids (ACs), with ACs having worse prognosis.
- A study of 15 L-CDs revealed two distinct subtypes, L-CD-PanC, likened to pancreatic tumors, and L-CD-NeU, akin to neuroendocrine tumors, differentiated by their genetic and epigenetic profiles.
- L-CD-PanC tumors showed changes related to metabolic and pancreatic genes, while L-CD-NeU tumors exhibited high mutational loads and specific environmental mutational signatures, suggesting different underlying causes and potential treatment implications.
Article Synopsis
- * Research indicates that activation patterns in the BLA differ based on the type of stimulus, with aversive stimuli causing stronger activation in specific medial areas of the BLA and stressful stimuli leading to longer activation durations.
- * The study highlights the need for further research into the molecular and circuit-level specifics of the BLA's activation during stress, with norepinephrine playing a key role in enhancing neuron responses in these situations.
This case report underscores the importance of utilizing E-VAC (endoscopic vacuum-assisted closure) in the treatment of a perforated duodenal ulcer complicated by the formation of a subphrenic abscess and septic shock. It showcases how E-VAC can effectively mitigate the risk of further complications, such as leakage, bleeding, or rupture, which are more commonly associated with traditional methods like stents, clips, or sutures. As a result, there is a significant reduction in mortality rates.
View Article and Find Full Text PDFAcute febrile illnesses are still a major cause of mortality and morbidity globally, particularly in low to middle income countries. The aim of this study was to determine any possible metabolic commonalities of patients infected with disparate pathogens that cause fever. Three liquid chromatography-mass spectrometry (LC-MS) datasets investigating the metabolic effects of malaria, leishmaniasis and Zika virus infection were used.
View Article and Find Full Text PDF