Publications by authors named "A NaserEddin"
Mammals withstand frequent and prolonged fasting periods due to hepatic production of glucose and ketone bodies. Because the fasting response is transcriptionally regulated, we asked whether enhancer dynamics impose a transcriptional program during recurrent fasting and whether this generates effects distinct from a single fasting bout. We found that mice undergoing alternate-day fasting (ADF) respond profoundly differently to a following fasting bout compared to mice first experiencing fasting.
View Article and Find Full Text PDFAs a key enzyme of the renin-angiotensin system (RAS), angiotensin-converting enzyme 2 (ACE2) is a validated receptor for SARS-CoV-2, linking RAS to COVID-19. Functional ACE1/ACE2 gene polymorphisms likely cause an imbalance in the ACE1/ACE2 ratio, triggering RAS imbalance and may contribute to COVID-19 complications. This study aimed to investigate four single nucleotide polymorphisms (SNPs) of ACE1 and ACE2 genes, three for ACE1 (rs4343, rs4342, rs4341) and one for ACE2 (rs2285666), in patients with COVID-19 among the Palestinian population.
View Article and Find Full Text PDFArticle Synopsis
- Echinococcus granulosus, a tapeworm responsible for cystic echinococcosis in humans, includes several genotypes that can cause this disease.
- The study utilized next-generation sequencing with a specific assay to differentiate these genotypes from human and animal samples, achieving 100% success in identifying and genotyping.
- Results confirmed the method's effectiveness in distinguishing closely related genotypes and revealed 12 distinct haplotypes, showcasing its potential as a diagnostic tool for E. granulosus infections.
Article Synopsis
- - The study investigates the genetic variation and spread of the SARS-CoV-2 Delta Variant in Palestine in August 2021, analyzing 571 positive COVID-19 samples from eight districts.
- - Key findings revealed four dominant lineages of the Delta Variant and identified eight spatial clusters, indicating significant localized transmission across regions, particularly in Al-Khalil.
- - Genetic diversity analysis showed high haplotype diversity but low nucleotide diversity, suggesting ongoing population dynamics and genetic differentiation between Palestinian districts, with implications for virus transmission and surveillance strategies.
Background And Aims: Genetic variants play a crucial role in the development of diabetic retinopathy (DR). Therefore, our study aimed to investigate the relationship between aldose reductase () (C106T) polymorphism with proliferative DR and associated risk factors in Palestinian type 2 diabetic patients.
Methods: A cross sectional study was conducted at St John Eye Hospital-East Jerusalem in 2020-2021 on patients with DR.