Nanographene-Based Polymeric Nanoparticles as Near-Infrared Emissive Neuronal Tracers.

Precise tracking of axonal transport is key to deciphering neuronal functions. To achieve long-term imaging at both ultrastructural and macroscopic resolutions, it is critical to develop fluorescent transport tracers with high photostability and biocompatibility. Herein, we report the investigation of nanographene (NG)-based polymeric nanoparticles (NPs) as near-infrared (NIR)-emissive neuronal tracers.

Use of a triple-coaxial system in coil embolization of a large bronchial artery aneurysm.

An 84-year-old man presented with a large bronchial artery aneurysm with a tortuous afferent artery. A triple-coaxial system was used to perform super-selective catheterization, consisting of a small microcatheter, a large microcatheter, and a 4-Fr catheter. The large microcatheter was successfully placed inside the aneurysm, and coil embolization was performed using large detachable coils to reduce the procedure cost.

Preferential graphitic-nitrogen formation in pyridine-extended graphene nanoribbons.

Graphene nanoribbons (GNRs), nanometer-wide strips of graphene, have garnered significant attention due to their tunable electronic and magnetic properties arising from quantum confinement. A promising approach to manipulate their electronic characteristics involves substituting carbon with heteroatoms, such as nitrogen, with different effects predicted depending on their position. In this study, we present the extension of the edges of 7-atom-wide armchair graphene nanoribbons (7-AGNRs) with pyridine rings, achieved on a Au(111) surface via on-surface synthesis.

Acid-induced fluorescence enhancement of piperazinylphenyl-substituted nanographene.

A dibenzo[,]ovalene (DBOV) derivative bay-substituted with two piperazinylphenyl (PZP) groups (DBOV-PZP) was synthesized. Comprehensive investigations of its photophysical properties revealed acid-induced fluorescence enhancement through the protonation of PZP units, leading to the suppression of the photoinduced electron transfer. These results pave the way towards "turn-on" type nanographenes for biosensing and optical imaging.

Metabolomic Profiling of Open-Angle Glaucoma Etiologic Endotypes: Tohoku Multi-Omics Glaucoma Study.

Purpose: The purpose of this study was to investigate biologically meaningful endotypes of open-angle glaucoma (OAG) by applying unsupervised machine learning to plasma metabolites.

Methods: This retrospective longitudinal cohort study enrolled consecutive patients aged ≥20 years with OAG at Tohoku University Hospital from January 2017 to January 2020. OAG was confirmed based on comprehensive ophthalmic examinations.