Publications by authors named "A Nakhmani"
Article Synopsis
- Airway wall thickening is measured using Pi10, which assumes uniform thickening across airways and only evaluates one airway level, making it less accurate.
- A new metric, PiSlope, was analyzed in a study involving 8,199 participants (smokers and non-smokers) to improve quantification of airway wall thickening by using the slope of luminal perimeter against wall thickness.
- Results showed that as disease severity increased, Pi10 values rose while PiSlope values decreased, indicating PiSlope's strong association with various respiratory health outcomes, including dyspnea and lung function decline.
Objective: To present a novel method for removing stimulus transient that exploits the absolute refractory period of electrically excitable neural tissues.
Background: Electrical stimulation often generates significant signal artifacts that can obscure important physiological signals. Removal of the artifact and understanding latent information from these signals could provide objective measures of circuit engagement, potentially driving advancements in neuromodulation research and therapies.
Rationale Emphysema progression is heterogeneous. Predicting temporal changes in lung density and detecting rapid progressors may facilitate selection of individuals for targeted therapies. Objective To test whether computed tomography (CT) radiomics can be used to predict changes in lung density and detect rapid progressors.
View Article and Find Full Text PDFBackground: Luminal narrowing is a hallmark feature of airway remodelling in COPD, but current measures focus on airway wall remodelling. Quantification of the natural increase in cumulative cross-sectional area along the length of the human airway tree can facilitate assessment of airway narrowing.
Methods: We analysed the airway trees of 7641 subjects enrolled in the multicentre COPDGene cohort.