Non-dialyzable uremic toxins and renal tubular cell damage in CKD patients: a systems biology approach.

Background: Chronic kidney disease presents global health challenges, with hemodialysis as a common treatment. However, non-dialyzable uremic toxins demand further investigation for new therapeutic approaches. Renal tubular cells require scrutiny due to their vulnerability to uremic toxins.

Engineered nanoparticles as Selinexor drug delivery systems across the cell membrane and related signaling pathways in cancer cells.

In the present work, molecular dynamics simulation is applied to evaluate the drug carrier efficiency of graphene oxide nanoflake (GONF) for loading of Selinexor (SXR) drug as well as the drug delivery by 2D material through the membrane in aqueous solution. In addition, to investigate the adsorption and penetration of drug-nanocarrier complex into the cell membrane, well-tempered metadynamics simulations and steered molecular dynamics (SMD) simulations were performed. Based on the obtained results, it is evident that intermolecular hydrogen bonds (HBs) and π-π interactions play a significant role in expediting the interaction between drug molecules and the graphene oxide (GO) nanosheet, ultimately resulting in the formation of a stable SXR-GO complex.

Zinc deficiency and febrile seizure: a systematic review and meta-analysis.

Background And Objectives: Zinc has been reported to be low in children with febrile seizure compared to febrile cases without seizures, but results are inconsistent. A meta-analysis was performed to systematically evaluate the serum level of zinc in febrile children aged between 6-72 months with or without seizures.

Material And Methods: A systematic search of databases was performed from January 2000 to January 2019.

Studying the Effects of Systemic Inflammatory Markers and Drugs on AVF Longevity through a Novel Clinical Intelligent Framework.

Although arteriovenous fistula is the preferred vascular access method, it has challenges in three phases of planning, maturation, and maintenance. We looked at the root of fistula challenges in the maintenance phase and found traces of inflammation. Accordingly, we investigated the role of systemic inflammation in this phase to understand its effects on post-maturation function and extract knowledge to help extend fistula longevity.