Association between sebum secretion and cardiac sympathetic dysfunction in Parkinson's disease.

Background: Patients with Parkinson's disease (PD) have α-synuclein (α-Syn) deposition in the skin, and decreased sebum secretion due to epidermal dysfunction. However, the relationship between sebum secretion and autonomic neuropathies is unknown.

Methods: Using the medical records in our facility, we identified patients newly diagnosed with PD on admission from August 2020 to December 2023.

Improvement of Heterologous Soluble Expression of L-amino Acid Oxidase Using Logistic Regression.

Successful implementation of enzymes in practical application hinges on the development of efficient mass production techniques. However, in a heterologous expression system, the protein is often unable to fold correctly and, thus, forms inclusion bodies, resulting in the loss of its original activity. In this study, we present a new and more accurate model for predicting amino acids associated with an increased L-amino acid oxidase (LAO) solubility.

Transition condition between memories of vibration and flow in the memory effect of paste.

Because of its plasticity, a densely packed colloidal suspension, called a paste, remembers directions of its motion, such as vibration and flow. When it dries, primary desiccation cracks propagate in a direction perpendicular to the direction of its vibrational motion and parallel to the direction of its flow motion, which are memory effects of paste. Application of an oscillatory shear strain to a paste using a rheometer reveals that the transition from memory of vibration to that of flow is induced when the amplitude of the oscillatory shear strain exceeds a threshold value.

Scale-free bursting activity in shrinkage induced cracking.

Based on computer simulations of a realistic discrete element model we demonstrate that shrinkage induced cracking of thin layers of heterogeneous materials, generating spectacular crack patterns, proceeds in bursts. These crackling pulses are characterized by scale free distributions of size and duration, however, with non-universal exponents depending on the system size and shrinking rate. On the contrary, local avalanches composed of micro-cracking events with temporal and spatial correlation are found to obey a universal power law statistics.