Carboxylated Zn-phthalocyanine attenuates brain Aβ in AD model mouse.

The deposition of aggregated amyloid β (Aβ) is considered as a key factor for Alzheimer's Disease (AD). Previously, we demonstrated that a carboxylated Zn-phthalocyanine (ZnPc) inhibits Aβ fibril formation, consequently protects neurons in culture. This study evaluated the effects of ZnPc on pathological changes in an AD mouse model (J20).

Anemia-associated smaller brain volume and sex differences: a cross-sectional study of magnetic resonance imaging in brain health checkups.

Introduction: Anemia is a risk factor for dementia development. However, few studies have examined the relationship between brain volume and anemia. This study aimed to analyze the association between anemia and brain volume using magnetic resonance imaging data from brain health checkups.

Effects of ankle dorsiflexion training on anticipatory postural adjustments during gait initiation in patients with Parkinson's disease.

Background: Freezing of gait (FOG) during gait initiation in patients with Parkinson's disease (PD) is associated with anticipatory postural adjustments (APAs) with diminishing amplitude, leading to a risk of falls. Assistance with ankle dorsiflexion function by external devices improve APAs during gait initiation, however, the effect of training to improve ankle dorsiflexion function on APAs during gait initiation is unclear.

Research Question: Does ankle dorsiflexion training improve APAs and FOG during gait initiation in patients with PD?

Method: This 4-week prospective controlled trial included 30 patients with PD, who were divided into two groups: the control group, which received only conventional inpatient rehabilitation, and the intervention group, which received ankle dorsiflexion training in addition to inpatient rehabilitation.

Analysis of COVID-19 nosocomial clusters in an Omicron strain epidemic: importance of patient education on infection control measures.

A cluster of 129 patients with coronavirus disease 2019 (COVID-19) nosocomial infections was analysed during the Omicron strain epidemic. The incubation period for nosocomial Omicron strain infections was found to be 3 days. The transmission route of the first patient with COVID-19 (FCP) in each room is a critical factor within these clusters.

Mid- to long-term clinical and radiological assessment of a short, titanium, porous plasma-splayed flat-tapered cementless femoral stem: An 8- to 12-year follow-up study.

Introduction: Short cementless stems offer advantages such as bone-stock preservation and minimally invasive insertion. Despite encouraging short- to midterm outcomes, the long-term clinical and radiological implications of short, titanium, and porous plasma-sprayed flat-tapered stems remain unclear.

Materials And Methods: A retrospective review of 138 primary total hip arthroplasties, conducted between 2010 and 2015 in 130 patients, with a minimum 8-year follow-up was performed.