Publications by authors named "A NICOLETTI"
Parkinson's Disease (PD) is a progressive neurodegenerative disorder affecting motor and cognitive functions, reducing the quality of life (QoL) for both patients and caregivers. This study explored correlations between clinical and psychological factors in early-stage PD patients and their caregivers, focusing on disease burden and caregiver stress. Nineteen PD patients and their caregivers were assessed.
View Article and Find Full Text PDFPancreatic cancer is one of the most aggressive cancers with a very poor 5-year survival rate and reduced therapeutic options when diagnosed in an advanced stage. The dismal prognosis of pancreatic cancer has guided significant efforts to discover novel biomarkers in order to anticipate diagnosis, increasing the population of patients who can benefit from curative surgical treatment. CA 19-9 is the reference biomarker that supports the diagnosis and guides the response to treatments.
View Article and Find Full Text PDFIntroduction: Non-motor symptoms (NMS) in Parkinson's disease (PD) can fluctuate daily, impacting patient quality of life. The Non-Motor Fluctuation Assessment (NoMoFA) Questionnaire, a recently validated tool, quantifies NMS fluctuations during ON- and OFF-medication states. Our study aimed to validate the Italian version of NoMoFA, comparing its results to the original validation and further exploring its clinimetric properties.
View Article and Find Full Text PDFPredicting biomass of arborescent individuals on sample plots using allometric models is an essential step in the computation of design-based forest biomass estimates. Nonetheless, there are few models for species with different growth forms, such as tree ferns. This study, therefore, sought to construct models to predict {aboveground.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates two phenotypes of Parkinson's Disease (PD) based on the timing of REM sleep behavior disorder (RBD) onset in relation to motor symptoms: "body first" (RBD before motor symptoms) and "brain first" (RBD after motor symptoms).
- Researchers analyzed striatal dopaminergic function in PD patients using imaging and found that the "body first" group exhibited more symmetrical motor impairment, higher cognitive decline, and distinctive imaging results compared to those with later onset RBD.
- The findings corroborate the SOC model's predictions, indicating different patterns of neurological function and cognitive impairment linked to the onset of RBD in PD.