Publications by authors named "A NENNA"
Article Synopsis
- The study analyzes bacteremia and antibiotic resistance in Gram-negative bacilli among patients with hematological malignancies and those undergoing hematopoietic stem cell transplants across different geographic regions.
- It includes 1,277 cases of bacteremia, revealing that Gram-negative bacilli were present in 60.3% of episodes, with a notable occurrence of multidrug-resistant organisms (MDROs) affecting 40.2% of these infections.
- Key risk factors for 30-day mortality identified include relapse of underlying disease, use of corticosteroids, and the presence of resistant bacteria, emphasizing the high mortality associated with carbapenem-resistant cases.
Extracorporeal membrane oxygenation (ECMO) has been widely used as a life support technique in COVID-19 acute respiratory distress syndrome (ARDS). The use of anticoagulation during ECMO support remains a topic of debate. The primary aim of this study is to demonstrate the safety and efficacy of using argatroban as an anticoagulant instead of heparin in patients with heparin-associated thrombocytopenia.
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- Multiple-drug-resistant (MDR) bacteria are highly resistant pathogens that lead to increased health risks and healthcare costs, making it important to monitor and prevent these infections, especially in hospital settings.
- A study focused on patients over 18 who tested positive for MDR intestinal colonization before cardiac surgery showed no significant impact on postoperative outcomes related to ICU stay, readmissions, or infection rates.
- The findings suggest that having a positive MDR rectal sample does not elevate the risk for patients undergoing cardiac surgery, indicating that pre-surgical antibiotic protocols may not need modification for these patients.
Cardiac Surgery and Transcatheter Intervention for Valvular Heart Disease in Carcinoid Syndrome: Risk Factors, Outcomes, and Evolving Therapeutic Strategies.
J Cardiovasc Dev Dis
November 2024
Carcinoid heart disease (CHD) affects right-sided valves and causes significant mortality and morbidity. Even though the pathophysiology of the disease is not entirely understood, it is known that chronic exposure to high levels of circulating serotonin is the main factor responsible for developing valvular heart disease. Cardiac imaging plays a critical role in the management of CHD, so the final diagnosis can be performed through multimodal imaging techniques and the measurement of biomarkers.
View Article and Find Full Text PDFDysfunctions in miRNA production have been recently investigated as predictors of neoplasms and their therapeutic strategies. In this review, we summarize the available knowledge on miRNAs and cardiac tumors (such as myxoma) and mediastinal tumors (such as thymoma) and propose new avenues for future research. MiRNAs are crucial for cardiac development through the expression of cardiac transcription factors (miR-335-5p), hinder the cell cycle by modulating the activity of transcription factors (miR-126-3p, miR-320a), modulate the production of inflammatory factors such as interleukins (miR-217), and interfere with cell proliferation or apoptosis (miR-218, miR-634 and miR-122).
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