[The multidirectional effects of thrombin and the possibility of their control in neurology].

The review presents the main physiological functions of thrombin. The procoagulant and anticoagulant activities of the key serine protease are discussed in both physiological and pathological conditions of hemostasis. The involvement of thrombin in atherogenesis, as well as its role as a mediator of vascular dysfunction and inflammation in both the peripheral and central nervous system, is highlighted.

[Endothelial dysfunction in COVID- 19 and cognitive impairment].

Endothelial dysfunction is an important mechanism underlying multiple organ and systems failure in COVID-19. The development of endothelial dysfunction in COVID-19 can disrupt organ perfusion and cause a procoagulant state, leading to both macro- and microvascular thrombotic events. Cognitive impairment is a common complication of COVID-19 that develop in acute and delayed periods and is not directly related to the severity of the underlying disease.

[Prognostic value of endothelial dysfunction and von Willebrand factor in acute and chronic hemispheric intracerebral hemorrhage].

Aim: To study the changes in endothelial dysfunction and von Willebrand factor activity in acute and chronic stages of hemispheric intracerebral hemorrhage (ICH) and their influence on clinical severity and functional recovery.

Material And Methods: Fifty patients with hemispheric ICH, aged 61.6±11.

[Dynamic of cerebrovascular disorders in patients with carotid stenosis].

Aim: To study the state of cerebral hemodynamics and platelet hemostasis in patients with carotid stenosis (CS).

Material And Methods: The prospective study included 123 patients with atherosclerotic CS. The 1st group included 53 patients (mean age 52±12.