Publications by authors named "A N Tsareva"
() remains a major threat worldwide, although only a fraction of infected individuals develops tuberculosis (TB). TB susceptibility is shaped by multiple genetic factors, and we performed comparative immunological analysis of two mouse strains to uncover relevant mechanisms underlying susceptibility and resistance. C57BL/6 mice are relatively TB-resistant, whereas I/St mice are prone to develop severe TB, partly due to the MHC-II allelic variant that shapes suboptimal CD4 T cell receptor repertoire.
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- Cancer of unknown primary (CUP) poses a major challenge, being a leading cause of cancer death despite better diagnostic methods.
- A novel genomic analysis using whole-exome sequencing (WES) and RNA sequencing (RNA-seq) helped tailor treatment for a patient with a history of multiple tumors and fast progression on chemotherapy.
- The approach resulted in significant improvements across all metastatic sites and underscores the need for personalized genomic profiling to effectively manage CUP and identify tumor origins.
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- Head and neck squamous cell carcinoma (HNSCC) is a common and aggressive cancer where many patients experience treatment-resistant recurrent or metastatic disease.
- A case study of a 48-year-old woman with HRAS G12S mutated HNSCC showed that treatment with tipifarnib, a farnesyltransferase inhibitor, led to an impressive 8-month partial response, despite her previous lack of success with other therapies.
- The research indicates that while tipifarnib is promising, resistance may arise through the activation of the AKT pathway, suggesting that combining tipifarnib with a PI3K inhibitor could enhance treatment effectiveness in HRAS-mutated HNSCC.
The role of B cells migrating to the lung and forming follicles during tuberculosis (TB) inflammation is still the subject of debate. In addition to their antibody production and antigen-presenting functions, B cells secrete different cytokines and chemokines, thus participating in complex networks of innate and adaptive immunity. Importantly, lung B-cells produce high amounts of the pleiotropic gp130 cytokine IL-6.
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- High intake of sugar-sweetened beverages (SSBs) negatively affects the health of youth, but there has been little monitoring of their consumption in Eastern Europe.
- This study analyzed data from 14 Eastern European countries from 2002 to 2018 to track trends in adolescent daily SSB consumption, focusing on variations based on family affluence.
- Results showed a decline in daily SSB intake in most countries, with the most affluent adolescents reducing their consumption more significantly than their less affluent peers, leading to shifts in consumption patterns among different socioeconomic groups.